Figure 2
Formulation dependent IL-4 plasma levels. Engrafted NOD-scid IL2R γnull mice were treated with 10 μg hIL-4 dissolved in PBS (IL-4; n = 4), 0.5% methylcellulose, 0.05% TWEEN 80 in PBS (Methylcellulose; n = 4) and 10 μg IL-4 formulated with 0.5% methylcellulose, 0.05% TWEEN 80 in PBS (IL-4 + Methylcellulose; n = 11) for five consecutive days (day 8–12). IL-4 serum levels were determined at day 10 24 h post administration. Human IL-4 mouse serum levels in the group “IL-4 + Methylcellulose” were significantly different from the other groups. (ANOVA , F = 4.3, p = 0.03).