Figure 7

ADSC-dependent signaling pathways targeting HL-1 cardiomyocyte proliferation. A) Treatment of serum-free cultured HL-1 cardiomyocytes with FBS or B) serum-free conditioned medium of IL-1β stimulated ADSC resulted in enhanced proliferation of HL-1 cardiomyocytes (p < 0.05). A, B) Addition of inhibitors of upstream and downstream of MAPK (RAS and MEK) or JAK/STAT (JAK1 and pSTAT3) inhibitors all resulted in a significant decrease of proliferation of HL-1 cardiomyocytes (p < 0.05). Graphs represent triplicates (with SEM) data from n = 3 independent experiments.