Figure 4

Cytokine profile of culture supernatants measured by multiplex luminex system. A) shows the increased levels of cytokines IL-6 and IL-1β/IL-1Ra ratio, and low levels of cytokines IFN-γ, IL-2, IL-12 and TNF-α in control co-cultures (without aATC or Th₁ cytokines) compared to culture supernatants containing aATC or aATC and Th₁ cytokines. B) Shows low levels of CXCL10/IP-10, CXCL9/MIG, CCL3/MIP-1α, CCL4/MIP-1β and CCL5/RANTES expression in control co-cultures (without aATC or Th₁ cytokines) compared to culture supernatants containing aATC or aATC and Th₁ cytokines. */**/*** signifies statistically significant differences (*P < 0.05, **P < 0.01, ***p<0.001).