Skip to main content
Figure 1 | Journal of Translational Medicine

Figure 1

From: Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial

Figure 1

Immunohistochemistry of Kv7 channels in human sural nerve fascicles in vitro. The presence of Kv7.2 subunits at peripheral nodes of Ranvier as well as in unmyelinated fibres of human sural nerve was verified immunohistochemically. A node of Ranvier evident under bright field illumination (i) shows immunoreactivity for Kv7.2 (ii and merge iii). In addition, unmyelinated fibres labelled with peripherin (iv) also show immunoreactivity for Kv7.2 (ii and merge v). In a separate preparation, Kv7.2 immunoreactivity (vii) and immunoreactivity for the non-specific voltage-gated sodium channel marker PanNav (vi) colocalise at a node of Ranvier (merge viii). Scale bars indicate 10 μm

Back to article page