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Figure 5 | Journal of Translational Medicine

Figure 5

From: Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production

Figure 5

Hirsutanol A activated mitochondria/cytochrome c signaling pathway. Cells were exposed to various concentrations of hirsutanol A for 3h. The ψm was determined by flow cytometry. Results are presented as means ± SD from 3 independent experiments. (** < 0.01 versus *) (A). Cells were first treated with 20μmol/L hirsutanol A for 24h. Proteins obtained from cytosolic and mitochondria fractions were detected by immunoblotting assay (B).

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