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Table 4 3-year overall survival and SPT-free survival rates according to the methylation status of the five selected genes and the 5-gene panel

From: TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors

Variables

Methylation status

Overall survival (%)

p

SPT-free survival (%)

p

CCNA1

U

50.2

0.578

97.8

0.001

M

34.5

62.0

DAPK

U

46.3

0.914

94.1

0.292

M

45.7

79.7

MGMT

U

44.4

0.714

88.5

0.527

M

48.2

77.4

SFRP1

U

43.1

0.494

91.7

0.160

M

43.9

79.1

TIMP3

U

52.8

0.183

100

0.007

M

40.5

74.9

5-gene panel

U

48.2

0.176

100

0.091

M

38.9

81.4

  1. SPT, Second Primary Tumor; U – unmethylated; M – methylated. Numbers in bold number reflect statistically significant associations.