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Table 4 3-year overall survival and SPT-free survival rates according to the methylation status of the five selected genes and the 5-gene panel

From: TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors

Variables Methylation status Overall survival (%) p SPT-free survival (%) p
CCNA1 U 50.2 0.578 97.8 0.001
M 34.5 62.0
DAPK U 46.3 0.914 94.1 0.292
M 45.7 79.7
MGMT U 44.4 0.714 88.5 0.527
M 48.2 77.4
SFRP1 U 43.1 0.494 91.7 0.160
M 43.9 79.1
TIMP3 U 52.8 0.183 100 0.007
M 40.5 74.9
5-gene panel U 48.2 0.176 100 0.091
M 38.9 81.4
  1. SPT, Second Primary Tumor; U – unmethylated; M – methylated. Numbers in bold number reflect statistically significant associations.