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Table 3 Correlation between clinical and pathological characteristics of HNSCC patients and aberrant methylation profile of CCNA1, DAPK, MGMT, SFRP1 , TIMP3 and the 5-gene panel in HNSCC samples

From: TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors

Characteristics Category CCNA1   p-value DAPK   p-value SFRP1   p-value TIMP3   p-value 5-gene panel p-value
U M   U M   U M   U M   U M  
Age < 60 yrs 30 (81) 7 (19) 0.007 20 (53) 18 (48) 0.446 17 (50) 17 (50) 0.024 22 (56) 17 (44) 0.081 13 (34.2) 25 (65.8) 0.016
> 60 yrs 15 (50) 15 (50) 13 (43) 17 (57) 5 (21) 19 (79)   11 (36) 20 (64) 3 (9.7) 28 (90.3)
Tumor site Oral cavity 26 (74) 9 (26) 0.530a 20 (56) 16 (44) 0.609a 15 (50) 15 (50) 0.055a 23 (62) 14 (38) 0.023 a 9 (25.0) 27 (75.0) 0.419
Larynx 13 (62) 8 (39) 8 (38) 13 (62) 5 (29) 12 (71)   7 (33) 14 (64) 6 (28.6) 15 (71.4)
Oropharynx 4 (57) 3 (43) 3 (43) 4 (57) 0 (0) 7 (100)   1 (13) 7 (87) 0 (0) 8 (100)
Hypopharynx 2 (50) 2 (50) 2 (50) 2 (50) 2 (50) 2 (50)   2 (50) 2 (50) 1 (25) 3 (75)
Second primary tumor Absent 44 (73) 16 (27) 0.004 a 31 (51) 30 (49) 0.429a 21 (41) 30 (59) 0.235a 33 (52) 30 (48) 0.012 a 16 (25.8) 46 (74.2) 0.188a
Present 1 (14) 6 (86) 2 (29) 5 (71) 1 (14) 6 (86)   0 (0) 7 (100) 0 (0) 7 (100)
  1. U – unmethylated, n (%); M – methylated, n (%), a – p-value calculated by Fisher’s Exact Test. Numbers in bold number reflect statistically significant associations.