Examples of whole tissue sections of PDAC cases immunostained for RKIP (x200). A: positive immunostaining for RKIP in PDAC. Note the absence of tumor buds. B: Normal pancreatic tissue (upper left) with retained RKIP-positivity. Reduced RKIPexpression in the adjacent PDAC. C: Reduced RKIP-expression in PDAC and absent RKIPexpression in the tumor buds (arrows).