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Figure 2 | Journal of Translational Medicine

Figure 2

From: Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC)

Figure 2

Representative examples of RKIP staining: A: normal pancreatic tissue with strong RKIP expression (x200); B: An example of PanIN (upper right) with reduced RKIP expression compared to the normal tissue (left side of the image; x200); C: An example of PDAC with low-grade budding and retained RKIP expression (x200); D: PDAC with loss of RKIP expression. A peripheral nerve (lower left) with strong RKIP staining (x200); E: PDAC with many tumor buds and loss of RKIP expression (x200); F: an example of PDAC with loss of RKIP expression in the buds (arrows) compared to the main tumor body (x400); G: PDAC with high-grade tumor budding and loss of RKIP expression (x200); H: Lymph node metastasis of PDAC with loss of RKIP expression (x200).

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