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Figure 5 | Journal of Translational Medicine

Figure 5

From: Lanthanum carbonate prevents accelerated medial calcification in uremic rats: role of osteoclast-like activity

Figure 5

mRNA expressions of all factors relative to GAPDH were examined by qRT-PCR. Compared to control group, ## (p < 0.01); Compared to CRF Group, **(p < 0.01). mRNA expression of CathepsinK (A), RANKL (C), Runx2 (E) and Osteocalcin (F) were highly expressed (p < 0.01 vs control group) along with increased RANKL/OPG ratio (D) while OPG mRNA (B) was down-regulated in CRF group (p < 0.01 vs control). Binding of serum phosphate caused significantly decrease of CathepsinK, RANKL, Runx2 and Osteocalcin expression by 53.9%, 41.7%, 51.4% and 73.3% respectively (p < 0.01 vs CRF) whereas expression of OPG mRNA was found to be increased 1.7-fold (p < 0.01 vs CRF). The local RANKL/OPG ratio exhibited remarkable reduction in 2%La group (p < 0.01 vs CRF).

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