From: VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses
Predictive model no. | siRNA features | No. of siRNA features | Pearson correlation coefficient* | ||
---|---|---|---|---|---|
Training (T1380) | Validation (V345) | ||||
1 | Mononucleotide frequency | 4 | 0.32 | 0.29 | |
2 | Dinucleotide frequency | 16 | 0.36 | 0.32 | |
3 | Trinucleotide frequency | 64 | 0.45 | 0.41 | |
4 | Tetranucleotide frequency | 256 | 0.48 | 0.44 | |
5 | Pentanucleotide frequency | 1024 | 0.52 | 0.48 | |
6 | Binary | 76 | 0.26 | 0.14 | |
7 | Thermodynamic features | 21 | 0.29 | 0.24 | |
8 | Secondary structure | 28 | 0.10 | 0.06 | |
9 | 1 + 2 + 3 + 4 + 5 | 1364 | 0.52 | 0.49 | |
10 | 6 + 9 | 1440 | 0.54 | 0.51 | |
11 | 6 + 7 + 9 | 1461 | 0.58 | 0.55 | |
12 | 6 + 7 + 8 + 9 | 1489 | 0.58 | 0.54 |