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Table 4 Comparison of VIRsiRNApred with existing siRNA efficacy prediction methods developed using mammalian homogeneous siRNA dataset

From: VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses

S.No

Reference

Technique

Url

siRNA data set

Pearson correlation coefficient

Train1

Val2

V345#

1

[35]

ANN

http://www.biopredsi.org

2431

 

0.66

0.60

Server not available

2

[32]

Linear

http://biodev.extra.cea.fr/DSIR/DSIR.html

2431

0.67

0.57

Server not working

3

[47]

Rule, SVM, RFR

http://www.bioinf.seu.edu.cn/siRNA/index.htm

3589

0.85

0.59

0.12

4

[38]

Linear

http://www.med.nagoya-u.ac.jp/neurogenetics/i_Score/i_score.html

2431

0.72

NA

0.05

5

[31]

SVM

NA

2431,

0.78

0.71

Server not available

6

[39]

Linear

http://rna.chem.t.u-tokyo.ac.jp/siexplorer.htm

702

0.77

0.60

0.18

7

[46]

SVM

http://www.imtech.res.in/raghava/sirnapred

2280

0.68

0.66

0.10

8

[40].

SVM

http://predictor.nchu.edu.tw/siPRED/

2431

0.77

0.53

0.09

9

[41]

Linear

http://biodev.extra.cea.fr/DSIR

2182

0.67

NA

Server not working

10

[42]

SVM

NA

2431

 

0.80

0.71

Server not available

  1. *Pearson Correlation Coefficient (PCC) is the correlation between experimental and predicted viral siRNA efficacy.
  2. 1Performance on n-fold training dataset of the study.
  3. 2Performance on test data set of the study.
  4. #V345 is the validation dataset of experimental viral siRNA.