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Table 4 Comparison of VIRsiRNApred with existing siRNA efficacy prediction methods developed using mammalian homogeneous siRNA dataset

From: VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses

S.No Reference Technique Url siRNA data set Pearson correlation coefficient
Train1 Val2 V345#
1 [35] ANN http://www.biopredsi.org 2431   0.66 0.60 Server not available
2 [32] Linear http://biodev.extra.cea.fr/DSIR/DSIR.html 2431 0.67 0.57 Server not working
3 [47] Rule, SVM, RFR http://www.bioinf.seu.edu.cn/siRNA/index.htm 3589 0.85 0.59 0.12
4 [38] Linear http://www.med.nagoya-u.ac.jp/neurogenetics/i_Score/i_score.html 2431 0.72 NA 0.05
5 [31] SVM NA 2431, 0.78 0.71 Server not available
6 [39] Linear http://rna.chem.t.u-tokyo.ac.jp/siexplorer.htm 702 0.77 0.60 0.18
7 [46] SVM http://www.imtech.res.in/raghava/sirnapred 2280 0.68 0.66 0.10
8 [40]. SVM http://predictor.nchu.edu.tw/siPRED/ 2431 0.77 0.53 0.09
9 [41] Linear http://biodev.extra.cea.fr/DSIR 2182 0.67 NA Server not working
10 [42] SVM NA 2431   0.80 0.71 Server not available
  1. *Pearson Correlation Coefficient (PCC) is the correlation between experimental and predicted viral siRNA efficacy.
  2. 1Performance on n-fold training dataset of the study.
  3. 2Performance on test data set of the study.
  4. #V345 is the validation dataset of experimental viral siRNA.