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Figure 2 | Journal of Translational Medicine

Figure 2

From: T and NK cells: two sides of tumor immunoevasion

Figure 2

Shared MHC-I ligands and tumor infiltration by T and NK cells. Schematic diagrams depicting tumor recognition by (A) a single immune receptor (NKG2A) expressed by both T and NK cells, and (C) two distinct receptors: the TcR expressed by T cells and Ly-49 expressed by NK cells, both specific for a single class of immune ligands (MHC-I molecules). Immunohistochemical stain (B) of NKG2A+ cells infiltrating (arrows) a human colorectal carcinoma lesion. These are found in the context of CD8+ T cell infiltrates, whereas CD56+ cells were shown to be less than 2 per microscopic field, therefore marginally if at all contributing to NKG2A staining[16]. Counterstained with Hematoxylin. Fluorescent confocal microscopy imaging of CD8+ T cells (D) and NK1.1+ cells (E), in red, infiltrating RMA murine lymphoma tumors expressing misfolded MHC class I molecules. Counterstained with Hoechst 33342. Size bars: 40 μm in all panels.

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