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Table 1 Lipid profiles of vehicle- and sildenafil-treated apolipoprotein E-deficient (apoE−/−) mice fed a Western-type diet and wild-type control (WT)

From: Sildenafil restores endothelial function in the apolipoprotein E knockout mouse

Parameter

WT

   apoE−/−

 

Vehicle

Sildenafil

Triglycerides (mg/dL)

61 ± 9

241 ± 36**

196 ± 46*

Total plasma cholesterol (mg/dL)

94 ± 5

1308 ± 145**

1310 ± 223**

LDL (mg/dL)

23 ± 6

180 ± 29**

190 ± 48**

HDL (mg/dL)

58 ± 4

15 ± 4**

10 ± 1**

VLDL + IDL (mg/dL)

26 ± 5

1115 ± 28**

1111 ± 48**

  1. Values are mean ± SEM of 5–10 mice per group. *p < 0.05 and **p < 0.01 vs. WT (one-way ANOVA).