Figure 4

Effect of sildenafil treatment on plaque deposition and oxidative stress. (A) Bar graph showing mean ± SEM values (in %) of plaque deposition in untreated and treated apoE^−/− mice compared to wild-type (WT) control mice. Photomicrographs are typical aorta cross-sections of each group of animals. Scale bar 500 μm. (B) Bar graph showing mean ± SEM values of dihydroethidium (DHE) labeling (in arbitrary units) comparing the 3 groups of animals. Photomicrographs above the graph are typical aorta cross-sections showing fluorescent DHE labeling. Scale bar 100 μm. *p < 0.05 and **p < 0.01 untreated apoE^−/− vs. WT; ^#p < 0.05 treated vs. untreated apoE^−/− vehicle (one-way ANOVA).