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Figure 1 | Journal of Translational Medicine

Figure 1

From: The chromatin remodelling component SMARCB1/INI1 influences the metastatic behavior of colorectal cancer through a gene signature mapping to chromosome 22

Figure 1

SMARCB1/INI1 expression analysis in Tissue Microarray of CRC and matched normal mucosa. (A) Examples of TMA cores representative of the normal mucosa and CRC specimens stained with SMARCB1/INI1; the immunostaining pattern allows to divide tumors into three categories, Neg, Low, High. (B) The box-plot shows the SMARCB1/INI1score (number of positive cells in 10-high power fields) in paired normal mucosa and tumor samples (60 cases). (C) SMARCB1/INI1 expression pattern expressed as percentage of cases for each category in all 134 CRCs. (D) Four representative frozen CRC specimens (T) and matched normal mucosa (N) from the same cohort of patients are analyzed by immunoblot. The β-actin is used as loading control to normalize SMARCB1/INI1 band intensities. The histogram reports quantitative expression levels of SMARCB1/INI1 after normalization. The box-plot shows that SMARCB1/INI1 expression detected by western blot in normal mucosa is lower than tumor samples (20 cases). The p value is reported in each graph.

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