Circulating microRNA: a novel potential biomarker for early diagnosis of Intracranial Aneurysm Rupture a case control study

Table 2 9 of the target genes that may be related to the formation, development and rupture of aneurysm

miRNA		Symbol	GO description
N	R
hsa-miR-22	↑	TRIB1	Negative regulation of smooth muscle cell proliferation/negative regulation of transcription factor activity
hsa-miR-671-5p	↑	SSX3	Positive regulation of smooth muscle cell proliferation/vascular endothelial growth factor receptor signaling pathway
hsa-miR-720	↑	ARFIP2	Actin cytoskeleton organization and biogenesis
hsa-miR-365	↓	BCL6B	Negative regulation of transcription from RNA polymerase II promoter
hsa-miR-498	↑	EP300	Positive regulation of transcription factor activity/positive regulation of transcription from RNA polymerase II promoter
hsa-miR-574	↓	EDN1	Positive regulation of smooth muscle cell proliferation/blood vessel morphogenesis
hsa-miR-106b	↑	CHAF1A	Vascular endothelial growth factor receptor activity/vascular endothelial growth factor receptor signaling pathway
hsa-miR-21	↑	PDCD6	Induction of apoptosis by extracellular signals
hsa-miR-936	↓	FMN2	Actin cytoskeleton organization and biogenesis/actin binding

N: Name of miRNA; R: Regulation of miRNA(↑up-regulated and ↓down-regulated) P: Significant P value, the smaller P is, the bigger the difference will be. Symbol: Name abbreviation of the regulated gene; GO description: Brief introduction of the protein translated from the gene.

ISSN: 1479-5876