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Figure 1 | Journal of Translational Medicine

Figure 1

From: Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory “Junn-Chenn-Zuou-SS”

Figure 1

PG27 inhibited IL-2 production from activated T cells in a concentration-dependent manner. Human peripheral blood T cells at a concentration of 1 × 106/mL were pretreated with various concentrations of PG27 for 2 h and then stimulated with PMA + ionomycin (shown as P + I) (A) or CD3/CD28 (B) for 24 h. The supernatants were collected for the determination of IL-2 concentrations. In parallel, cell survival in the various conditions was determined by trypan blue exclusion assays (C). The results shown are from independent experiments. Each experiment was performed in triplicate using T cells from at least 3 different donors.

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