Table 5 Hazard ratios of CRC risk defined by different tumour characteristics in relation to BMI, WHR and waist circumference in men
Tumour characteristics | Quartiles | BMI | WHR | Waist | |||
|---|---|---|---|---|---|---|---|
Number of cases | Cases | HR | Cases | HR | Cases | HR | |
Positive nuclear beta-catenin | 1 | 33 | 1.00 | 29 | 1.00 | 26 | 1.00 |
2 | 31 | 0.90(0.54-1.48) | 28 | 1.21(0.71-2.08) | 27 | 0.90(0.52-1.56) | |
3 | 37 | 0.97(0.60-1.59) | 43 | 1.60(0.99-2.59) | 47 | 1.36(0.84-2.23) | |
4 | 50 | 1.52(0.96-2.41) | 51 | 2.14(1.34-3.42)* | 51 | 1.66(1.02-2.69) | |
p trend | 0.050 | 0.001 | 0.009 | ||||
Negative nuclear beta-catenin | 1 | 25 | 1.00 | 30 | 1.00 | 21 | 1.00 |
2 | 15 | 0.57(0.29-1.10) | 18 | 0.78(0.43-1.45) | 11 | 0.43(0.20-0.91) | |
3 | 21 | 0.72(0.39-1.33) | 26 | 0.98(0.57-1.68) | 33 | 1.21(0.69-2.12) | |
4 | 38 | 1.51(0.86-2.57) | 25 | 0.96(0.54-1.69) | 34 | 1.27(0.72-2.23) | |
p trend | 0.074 | 0.993 | 0.076 | ||||
CyclinD1 positive | 1 | 47 | 1.00 | 45 | 1.00 | 39 | 1.00 |
2 | 33 | 0.69(0.44-1.09) | 39 | 1.13(0.72-1.77) | 29 | 0.62(0.38-1.02) | |
3 | 50 | 0.93(0.61-1.42) | 54 | 1.33(0.89-2.00) | 63 | 1.22(0.80-1.84) | |
4 | 66 | 1.46(0.99-2.16) | 58 | 1.61(1.08-1.42) | 65 | 1.40(0.93-2.10) | |
p trend | 0.019 | 0.015 | 0.009 | ||||
CyclinD1 negative | 1 | 11 | 1.00 | 14 | 1.00 | 8 | 1.00 |
2 | 12 | 0.95(0.41-2.19) | 6 | 0.48(0.17-1.32) | 9 | 1.02(0.39-2.64) | |
3 | 10 | 0.78(0.33-1.86) | 17 | 1.28(0.63-2.61) | 17 | 1.64(0.70-3.84) | |
4 | 22 | 1.75(0.83-3.71) | 18 | 1.32(0.63-2.72) | 21 | 2.01(0.87-4.64) | |
p trend | 0.146 | 0.211 | 0.046 | ||||
p53 positive (>50%) | 1 | 23 | 1.00 | 25 | 1.00 | 16 | 1.00 |
2 | 22 | 0.89(0.49-1.62) | 24 | 1.18(0.66-2.12) | 21 | 1.05(0.54-2.04) | |
3 | 32 | 1.17(0.67-2.04) | 33 | 1.43(0.84-2.44) | 41 | 1.85(1.02-3.33) | |
4 | 42 | 1.69(0.99-2.88) | 37 | 1.72(1.02-2.91) | 41 | 2.05(1.14-3.68) | |
p trend | 0.023 | 0.033 | 0.003 | ||||
P53 negative (<50%) | 1 | 34 | 1.00 | 32 | 1.00 | 30 | 1.00 |
2 | 23 | 0.65(0.38-1.13) | 22 | 0.91(0.52-1.59) | 16 | 0.48(0.26-0.89) | |
3 | 28 | 0.73(0.43-1.24) | 38 | 1.33(0.82-2.15) | 40 | 1.05(0.64-1.71) | |
4 | 46 | 1.44(0.90-2.30) | 39 | 1.52(0.93-2.47) | 45 | 1.25(0.76-2.03) | |
p trend | 0.084 | 0.048 | 0.070 | ||||
MSI | 1 | 5 | 1.00 | 6 | 1.00 | 5 | 1.00 |
2 | 5 | 0.98(0.28-3.42) | 5 | 1.27(0.39-4.18) | 4 | 0.73(0.20-2.72) | |
3 | 6 | 0.95(0.27-3.34) | 9 | 1.82(0.64-5.15) | 9 | 1.58(0.53-4.75) | |
4 | 11 | 2.47(0.84-7.26) | 7 | 1.52(0.48-4.80) | 9 | 1.50(0.49-4.65) | |
p trend | 0.082 | 0.344 | 0.272 | ||||
MSS | 1 | 53 | 1.00 | 55 | 1.00 | 43 | 1.00 |
2 | 40 | 0.72(0.47-1.10) | 40 | 0.90(0.59-1.39) | 34 | 0.67(0.42-1.06) | |
3 | 50 | 0.84(0.56-1.25) | 58 | 1.14(0.78-1.67) | 67 | 1.16(0.78-1.73) | |
4 | 73 | 1.37(0.95-1.99) | 63 | 1.36(0.93-1.98) | 72 | 1.39(0.94-2.05) | |
p trend | 0.053 | 0.071 | 0.012 | ||||