Skip to main content

Advertisement

Table 5 Hazard ratios of CRC risk defined by different tumour characteristics in relation to BMI, WHR and waist circumference in men

From: Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study

Tumour characteristics Quartiles BMI WHR Waist
Number of cases   Cases HR Cases HR Cases HR
Positive nuclear beta-catenin 1 33 1.00 29 1.00 26 1.00
2 31 0.90(0.54-1.48) 28 1.21(0.71-2.08) 27 0.90(0.52-1.56)
3 37 0.97(0.60-1.59) 43 1.60(0.99-2.59) 47 1.36(0.84-2.23)
4 50 1.52(0.96-2.41) 51 2.14(1.34-3.42)* 51 1.66(1.02-2.69)
  p trend   0.050   0.001   0.009
Negative nuclear beta-catenin 1 25 1.00 30 1.00 21 1.00
2 15 0.57(0.29-1.10) 18 0.78(0.43-1.45) 11 0.43(0.20-0.91)
3 21 0.72(0.39-1.33) 26 0.98(0.57-1.68) 33 1.21(0.69-2.12)
4 38 1.51(0.86-2.57) 25 0.96(0.54-1.69) 34 1.27(0.72-2.23)
  p trend   0.074   0.993   0.076
CyclinD1 positive 1 47 1.00 45 1.00 39 1.00
2 33 0.69(0.44-1.09) 39 1.13(0.72-1.77) 29 0.62(0.38-1.02)
3 50 0.93(0.61-1.42) 54 1.33(0.89-2.00) 63 1.22(0.80-1.84)
4 66 1.46(0.99-2.16) 58 1.61(1.08-1.42) 65 1.40(0.93-2.10)
  p trend   0.019   0.015   0.009
CyclinD1 negative 1 11 1.00 14 1.00 8 1.00
2 12 0.95(0.41-2.19) 6 0.48(0.17-1.32) 9 1.02(0.39-2.64)
3 10 0.78(0.33-1.86) 17 1.28(0.63-2.61) 17 1.64(0.70-3.84)
4 22 1.75(0.83-3.71) 18 1.32(0.63-2.72) 21 2.01(0.87-4.64)
  p trend   0.146   0.211   0.046
p53 positive (>50%) 1 23 1.00 25 1.00 16 1.00
2 22 0.89(0.49-1.62) 24 1.18(0.66-2.12) 21 1.05(0.54-2.04)
3 32 1.17(0.67-2.04) 33 1.43(0.84-2.44) 41 1.85(1.02-3.33)
4 42 1.69(0.99-2.88) 37 1.72(1.02-2.91) 41 2.05(1.14-3.68)
  p trend   0.023   0.033   0.003
P53 negative (<50%) 1 34 1.00 32 1.00 30 1.00
2 23 0.65(0.38-1.13) 22 0.91(0.52-1.59) 16 0.48(0.26-0.89)
3 28 0.73(0.43-1.24) 38 1.33(0.82-2.15) 40 1.05(0.64-1.71)
4 46 1.44(0.90-2.30) 39 1.52(0.93-2.47) 45 1.25(0.76-2.03)
  p trend   0.084   0.048   0.070
MSI 1 5 1.00 6 1.00 5 1.00
2 5 0.98(0.28-3.42) 5 1.27(0.39-4.18) 4 0.73(0.20-2.72)
3 6 0.95(0.27-3.34) 9 1.82(0.64-5.15) 9 1.58(0.53-4.75)
4 11 2.47(0.84-7.26) 7 1.52(0.48-4.80) 9 1.50(0.49-4.65)
  p trend   0.082   0.344   0.272
MSS 1 53 1.00 55 1.00 43 1.00
2 40 0.72(0.47-1.10) 40 0.90(0.59-1.39) 34 0.67(0.42-1.06)
3 50 0.84(0.56-1.25) 58 1.14(0.78-1.67) 67 1.16(0.78-1.73)
4 73 1.37(0.95-1.99) 63 1.36(0.93-1.98) 72 1.39(0.94-2.05)
  p trend   0.053   0.071   0.012
  1. Adjusted for age, level of education, smoking habits and alcohol consumption.
  2. *Heterogeneity analysis with p < 0.05.