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Table 3 Hazard ratios of CRC risk defined by different tumour characteristics in relation to BMI, WHR and waist and hip circumference in women

From: Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study

Tumour characteristics Quartiles BMI WHR Waist
Number of cases   Cases RR Cases RR Cases RR
Positive nuclear beta-catenin 1 20 1.00 43 1.00 23 1.00
2 40 1.73(1.00-2.97) 29 0.83(0.52-1.34) 33 0.97(0.57-1.67)
3 43 1.79(1.05-3.05) 40 0.92(0.59-1.43) 51 1.40(0.85-2.30)
4 55 2.25(1.33-3.80)* 46 1.20(0.79-1.84) 51 1.36(0.82-2.25)
  p trend   0.004   0.366   0.097
Negative nuclear beta-catenin 1 22 1.00 24 1.00 16 1.00
2 29 1.20(0.69-2.09) 25 1.21(0.69-2.12) 25 1.16(0.62-2.18)
3 28 1.06(0.60-1.87) 32 1.31(0.77-2.22) 37 1.51(0.84-2.73)
4 24 0.89(0.49-1.61) 22 0.97(0.54-1.74) 25 1.00(0.53-1.90)
  p trend   0.588   0.952   0.860
CyclinD1 positive 1 35 1.00 55 1.00 31 1.00
2 53 1.31(0.85-2.02) 48 1.07(0.72-1.58) 49 1.09(0.69-1.72)
3 61 1.42(0.94-2.17) 62 1.12(0.77-1.62) 75 1.51(0.99-2.31)
4 65 1.48(0.97-2.25) 49 0.98(0.66-1.45) 59 1.14(0.73-1.78)
  p trend   0.076   0.997   0.357
CyclinD1 negative 1 7 1.00 10 1.00 8 1.00
2 12 1.64(0.64-4.20) 7 0.80(0.31-2.11) 7 0.69(0.25-1.90)
3 9 1.19(0.44-3.23) 12 1.18(0.51-2.74) 12 1.08(0.44-2.66)
4 18 2.46(1.00-6.02) 17 1.92(0.87-4.22) 19 1.81(0.78-4.21)
  p trend   0.071   0.066   0.063
p53 positive (>50%) 1 19 1.00 30 1.00 21 1.00
2 33 1.51(0.85-2.67) 27 1.10(0.65-1.86) 27 0.89(0.50-1.59)
3 38 1.63(0.93-2.84) 35 1.20(0.73-1.96) 40 1.20(0.70-2.05)
4 39 1.65(0.94-2.89) 37 1.41(0.87-2.31) 41 1.23(0.72-2.10)
  p trend   0.103   0.158   0.248
P53 negative(<50%) 1 23 1.00 35 1.00 18 1.00
2 33 1.29(0.75-2.21) 28 0.96(0.58-1.58) 29 1.16(0.64-2.09)
3 33 1.23(0.72-2.11) 39 1.08(0.68-1.71) 49 1.77(1.03-3.06)
4 44 1.61(0.96-2.71) 31 0.95(0.58-1.54) 37 1.28(0.72-2.27)
  p trend   0.091   0.953   0.236
MSI 1 10 1.00 11 1.00 6 1.00
2 9 0.79(0.32-1.95) 10 1.08(0.46-2.55) 13 1.53(0.58-4.05)
3 14 1.09(0.48-2.48) 14 1.22(0.56-2.70) 16 1.59(0.62-4.10)
4 12 0.91(0.39-2.25) 10 0.96(0.41-2.27) 10 0.95(0.34-2.65)
  p trend   0.972   0.971   0.765
MSS 1 31 1.00 57 1.00 33 1.00
2 56 1.60(1.03-2.50) 44 0.94(0.63-1.40) 43 0.92(0.58-1.46)
3 55 1.51(0.97-2.36) 55 0.96(0.66-1.40) 69 1.37(0.90-2.08)
4 70 1.90(1.23-2.93) 56 1.10(0.76-1.60) 67 1.31(0.85-2.00)
  p trend   0.009   0.625   0.065
  1. Adjusted for age, level of education, smoking habits and alcohol consumption.
  2. *Heterogeneity analysis with p < 0.05.