Table 3 Hazard ratios of CRC risk defined by different tumour characteristics in relation to BMI, WHR and waist and hip circumference in women
Tumour characteristics | Quartiles | BMI | WHR | Waist | |||
|---|---|---|---|---|---|---|---|
Number of cases | Cases | RR | Cases | RR | Cases | RR | |
Positive nuclear beta-catenin | 1 | 20 | 1.00 | 43 | 1.00 | 23 | 1.00 |
2 | 40 | 1.73(1.00-2.97) | 29 | 0.83(0.52-1.34) | 33 | 0.97(0.57-1.67) | |
3 | 43 | 1.79(1.05-3.05) | 40 | 0.92(0.59-1.43) | 51 | 1.40(0.85-2.30) | |
4 | 55 | 2.25(1.33-3.80)* | 46 | 1.20(0.79-1.84) | 51 | 1.36(0.82-2.25) | |
p trend | 0.004 | 0.366 | 0.097 | ||||
Negative nuclear beta-catenin | 1 | 22 | 1.00 | 24 | 1.00 | 16 | 1.00 |
2 | 29 | 1.20(0.69-2.09) | 25 | 1.21(0.69-2.12) | 25 | 1.16(0.62-2.18) | |
3 | 28 | 1.06(0.60-1.87) | 32 | 1.31(0.77-2.22) | 37 | 1.51(0.84-2.73) | |
4 | 24 | 0.89(0.49-1.61) | 22 | 0.97(0.54-1.74) | 25 | 1.00(0.53-1.90) | |
p trend | 0.588 | 0.952 | 0.860 | ||||
CyclinD1 positive | 1 | 35 | 1.00 | 55 | 1.00 | 31 | 1.00 |
2 | 53 | 1.31(0.85-2.02) | 48 | 1.07(0.72-1.58) | 49 | 1.09(0.69-1.72) | |
3 | 61 | 1.42(0.94-2.17) | 62 | 1.12(0.77-1.62) | 75 | 1.51(0.99-2.31) | |
4 | 65 | 1.48(0.97-2.25) | 49 | 0.98(0.66-1.45) | 59 | 1.14(0.73-1.78) | |
p trend | 0.076 | 0.997 | 0.357 | ||||
CyclinD1 negative | 1 | 7 | 1.00 | 10 | 1.00 | 8 | 1.00 |
2 | 12 | 1.64(0.64-4.20) | 7 | 0.80(0.31-2.11) | 7 | 0.69(0.25-1.90) | |
3 | 9 | 1.19(0.44-3.23) | 12 | 1.18(0.51-2.74) | 12 | 1.08(0.44-2.66) | |
4 | 18 | 2.46(1.00-6.02) | 17 | 1.92(0.87-4.22) | 19 | 1.81(0.78-4.21) | |
p trend | 0.071 | 0.066 | 0.063 | ||||
p53 positive (>50%) | 1 | 19 | 1.00 | 30 | 1.00 | 21 | 1.00 |
2 | 33 | 1.51(0.85-2.67) | 27 | 1.10(0.65-1.86) | 27 | 0.89(0.50-1.59) | |
3 | 38 | 1.63(0.93-2.84) | 35 | 1.20(0.73-1.96) | 40 | 1.20(0.70-2.05) | |
4 | 39 | 1.65(0.94-2.89) | 37 | 1.41(0.87-2.31) | 41 | 1.23(0.72-2.10) | |
p trend | 0.103 | 0.158 | 0.248 | ||||
P53 negative(<50%) | 1 | 23 | 1.00 | 35 | 1.00 | 18 | 1.00 |
2 | 33 | 1.29(0.75-2.21) | 28 | 0.96(0.58-1.58) | 29 | 1.16(0.64-2.09) | |
3 | 33 | 1.23(0.72-2.11) | 39 | 1.08(0.68-1.71) | 49 | 1.77(1.03-3.06) | |
4 | 44 | 1.61(0.96-2.71) | 31 | 0.95(0.58-1.54) | 37 | 1.28(0.72-2.27) | |
p trend | 0.091 | 0.953 | 0.236 | ||||
MSI | 1 | 10 | 1.00 | 11 | 1.00 | 6 | 1.00 |
2 | 9 | 0.79(0.32-1.95) | 10 | 1.08(0.46-2.55) | 13 | 1.53(0.58-4.05) | |
3 | 14 | 1.09(0.48-2.48) | 14 | 1.22(0.56-2.70) | 16 | 1.59(0.62-4.10) | |
4 | 12 | 0.91(0.39-2.25) | 10 | 0.96(0.41-2.27) | 10 | 0.95(0.34-2.65) | |
p trend | 0.972 | 0.971 | 0.765 | ||||
MSS | 1 | 31 | 1.00 | 57 | 1.00 | 33 | 1.00 |
2 | 56 | 1.60(1.03-2.50) | 44 | 0.94(0.63-1.40) | 43 | 0.92(0.58-1.46) | |
3 | 55 | 1.51(0.97-2.36) | 55 | 0.96(0.66-1.40) | 69 | 1.37(0.90-2.08) | |
4 | 70 | 1.90(1.23-2.93) | 56 | 1.10(0.76-1.60) | 67 | 1.31(0.85-2.00) | |
p trend | 0.009 | 0.625 | 0.065 | ||||