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Table 2 Hazard ratios of CRC risk defined by different tumour characteristics in relation to height, weight and hip circumference in women

From: Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study

Tumour characteristics

Quartiles

Height

Weight

Hip

Number of cases

 

Cases

RR

Cases

RR

Cases

RR

Positive nuclear beta-catenin

1

31

1.00

22

1.00

19

1.00

2

56

1.34(0.86-2.08)

39

1.50(0.89-2.52)

38

1.41(0.81-2.46)

3

39

1.32(0.82-2.13)

46

2.04(1.22-3.41)

37

1.28(0.73-2.26)

4

32

1.17(0.70-1.96)

51

1.87(1.12-3.10)

64

1.93(1.14-3.26)

 

p trend

 

0.593

 

0.010

 

0.014

Negative nuclear beta-catenin

1

20

1.00

19

1.00

21

1.00

2

30

1.13(0.64-2.00)

32

1.46(0.82-2.57)

21

0.72(0.39-1.32)

3

26

1.33(0.74-2.40)

22

1.17(0.63-2.17)

30

1.03(0.58-1.81)

4

27

1.56(0.86-2.84)

30

1.31(0.73-2.33)

31

0.88(0.50-1.55)

 

p trend

 

0.113

 

0.599

 

0.985

CyclinD1 positive

1

39

1.00

35

1.00

34

1.00

2

70

1.36(0.92-2.02)

54

1.32(0.86-2.02)

45

0.92(0.59-1.44)

3

53

1.47(0.97-2.23)

56

1.57(1.03-2.41)

57

1.11(0.72-1.70)

4

52

1.62(1.05-2.49)

69

1.60(1.06-2.42)

78

1.28(0.85-1.93)

 

p trend

 

0.031

 

0.019

 

0.110

CyclinD1 negative

1

12

1.00

6

1.00

6

1.00

2

14

0.80(0.37-1.73)

12

1.70(0.63-4.54)

11

1.42(0.52-3.85)

3

12

0.89(0.39-1.99)

14

2.38(0.91-6.22)

11

1.49(0.55-4.07)

4

8

0.61(0.24-1.53)

14

1.96(0.75-5.12)

18

2.13(0.83-5.48)

 

p trend

 

0.365

 

0.155

 

0.103

p53 positive (>50%)

1

30

1.00

25

1.00

19

1.00

2

46

1.16(0.73-1.84)

32

1.07(0.63-1.80)

32

1.19(0.67-2.10)

3

32

1.10(0.67-1.83)

34

1.31(0.77-2.20)

34

1.19(0.67-2.10)

4

21

0.78(0.43-1.39)

38

1.21(0.72-2.00)

44

1.31(0.76-2.28)

 

p trend

 

0.431

 

0.370

 

0.364

P53 negative (<50%)

1

25

1.00

16

1.00

21

1.00

2

40

1.39(0.82-2.37)

35

1.92(1.06-3.47)

25

0.85(0.48-1.53)

3

33

1.64(0.94-2.84)

37

2.36(1.31-4.26)

35

1.18(0.68-2.04)

4

39

2.17(1.25-3.76)*

45

2.36(1.33-4.21)

52

1.47(0.87-2.47)

 

p trend

 

0.004

 

0.004

 

0.042

MSI

1

11

1.00

8

1.00

9

1.00

2

14

1.01(0.46-2.23)

12

1.35(0.55-3.13)

9

0.68(2.271.71)

3

9

0.96(0.39-2.33)

11

1.49(0.60-3.71)

13

0.9(0.40-2.21)

4

11

1.43(0.61-3.38)

14

1.49(0.62-3.59)

14

0.81(0.34-1.90)

 

p trend

 

0.477

 

0.387

 

0.864

MSS

1

41

1.00

30

1.00

27

1.00

2

67

1.20(0.81-1.78)

58

1.64(0.05-2.55)

50

1.33(0.83-2.13)

3

56

1.39(0.92-2.09)

55

1.79(1.14-2.80)

52

1.34(0.84-2.13)

4

48

1.28(0.83-1.97)

69

1.87(1.21-2.88)

83

1.85(1.18-2.88)

 

p trend

 

0.203

 

0.008

 

0.005

  1. Adjusted for age, level of education, smoking habits and alcohol consumption.
  2. *Heterogeneity analysis with p < 0.05.