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Figure 1 | Journal of Translational Medicine

Figure 1

From: NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2

Figure 1

Structure of single chain triplebody SPM-2. ScFv domains (colored in the diagram) specific for CD33, CD16 and CD123, respectively, were connected by two (Gly4Ser)x4 linkers (black lines) into a single polypeptide chain. The distal scFv domains specific for CD33 (orange) and CD123 (green), bind targets on the same AML blast while the central scFv domain (blue) binds CD16 on NK cells. Antigen binding sites are indicated by the triangular pockets.

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