Effect of CDH12 on cell proliferation and cell cycle in CRC cell lines. A. Cell numbers at 0, 24, 48, 72,96 and 120 h was measured by CCK-8 assays. B: Proportion of cells in various phases of the cell cycle. The results are means of three independent experiments ± S.D (*:P<0.05). C: Representative histograms depicting cell cycle profiles of cells transiently transfected with shCDH12 or controls.