Figure 2

Schematic structure of Myosin XVa and conservation analysis. Diagram of the human MYO15A domains which consists of an alternatively spliced 1223-amino-acid N-terminus encoded by exon 2, a motor domain, two IQ motifs, and two MyTH4 domains, two FERM domains, a PDZ domain and an SH3 domain; IVS25 + 3G > A occur between IQ and MyTH4 domain, V2792A occur in the FERMa domain. Protein or sequence alignment showed conservation of residues MYO15A IVS25 + 3 and V2792 across nine species. These two mutations occur at an evolutionarily conserved nucleotide or amino acid (in red).