Skip to main content

Advertisement

Table 2 Proteins showing differential responses

From: Wound outcome in combat injuries is associated with a unique set of protein biomarkers

Spot No. IPI No. Gene Name Protein Name Mascot Score Fold Change (Healed/ Dehisced) T-test Th. MW Th. pI
59 IPI00440484 PER1 Period Circadian protein homolog 1 133 -1.23 0.0414 137667 5.73
95* IPI00645206 PCDH17 Isoform 1 of Protocadherin 17 131 -1.22 0.0121 127405 5.03
99* IPI00235407 STK36 Isoform 1 of Serine/threonine protein kinase 3 142 -1.24 0.0018 145728 5.57
102 IPI00185661 USP32 Ubiquitin carboxyl terminal hydrolase 32 125 -1.2 0.0164 145671 6.18
106 IPI00470744 PARG Isoform 2 of Poly (ADP-ribose) glycohydrolase 113 -1.22 0.0106 103503 5.58
168* IPI00290328 PTPRJ Receptor type tyrosine protein phosphotase precursor 130 -1.51 0.0061 152960 5.8
195* IPI00017601 CP Ceruloplasmin 101 -1.27 0.0116 122983 5.44
198* IPI00017601 CP Ceruloplasmin 121 -1.39 0.0076 122983 5.44
199 IPI00017601 CP Ceruloplasmin 182 -1.31 0.0095 122983 5.44
200 IPI00017601 CP Ceruloplasmin 116 -1.33 0.0075 122983 5.44
201 IPI00017601 CP Ceruloplasmin 112 -1.3 0.0254 122983 5.44
202 IPI00017601 CP Ceruloplasmin 154 -1.31 0.0130 122983 5.44
329 IPI00011736 PIK3R2 Phosphatidylinositol 3 kinase regulatory subunit 2 88 1.26 0.0259 81837 6.03
330 IPI00783987 C3 Complement C3 115 1.55 0.0003 188569 6.02
333 IPI00011736 PIK3R2 Phosphatidylinositol 3 kinase regulatory subunit 2 111 1.25 0.0046 81837 6.03
337 IPI00783987 C3 Complement C3 88 1.53 0.0104 188569 6.02
341* IPI00783987 C3 Complement C3 147 1.56 0.0006 188569 6.02
343* IPI00783987 C3 Complement C3 189 1.62 0.0006 188569 6.02
344 IPI00783987 C3 Complement C3 120 1.69 0.0048 188569 6.02
345 IPI00783987 C3 Complement C3 79 1.59 0.0125 188569 6.02
347 IPI00783987 C3 Complement C3 104 1.52 0.0339 188569 6.02
375* IPI00607814 XPNPEP1 Xaa-Pro aminopeptidase 1 Isoform 2 121 1.23 0.0415 72746 5.67
389 IPI00157535 EPS8L1 Isoform 4 of Epigrowth factor receptor kinase subunit 8 118 1.23 0.0168 88920 6.49
436 IPI00009089 FRS3 Fibroblast growth factor receptor substrate 3 121 -1.28 0.0198 55169 6.81
582 IPI00301255 IGSF21 Immunoglobulin superfamily member 21 109 -1.23 0.0480 51855 6.48
602 IPI00329555 F7 Isoform A of Coagulation factor VII 178 -1.54 0.0232 53043 6.91
607 IPI00329555 F7 Isoform A of Coagulation factor VII 130 -1.37 0.0462 53043 6.91
787 IPI00021891 FGG Fibrinogen gamma chain 1 135 1.33 0.0267 51511 5.37
794 IPI00847635 SERPINA3 Isoform 1 of alpha-1-antichymotrypsin 146 1.57 0.0067 47792 5.33
800 IPI00847635 SERPINA3 Isoform 1 of alpha-1-antichymotrypsin 216 1.22 0.0273 47792 5.33
814 IPI00219330 ILF3 Isoform 5 of Interleukin enhancer binding factor 3 252 -1.35 0.0205 74959 8.4
869 IPI00783625 SERPINB5 Isoform 1 of Serpin B5 120 1.27 0.0356 42530 5.72
872* IPI00847635 SERPINA3 Isoform 1 of alpha-1-antichymotrypsin 111 1.39 0.0456 47792 5.33
876 IPI00847635 SERPINA3 Isoform 1 of alpha-1-antichymotrypsin 283 1.24 0.0424 47792 5.33
976 IPI00004657 HLA-B HLA class 1 histocompatibility antigen 102 1.27 0.0150 40777 5.57
980 IPI00004657 HLA-B HLA class 1 histocompatibility antigen 121 1.34 0.0383 40777 5.57
981 IPI00004657 HLA-B HLA class 1 histocompatibility antigen 101 1.57 0.0008 40777 5.57
1080 IPI00166729 AZGP1 Zinc alpha 2 glycoprotein precursor 147 -1.34 0.0031 34258 5.71
1177 IPI00555812 GC Vitamin D binding protein precursor 104 -1.28 0.0151 52963 5.4
1186 IPI00641737 HP Haptoglobin 92 -1.29 0.0374 45205 6.13
1374 IPI00978715 CLU Clusterin 109 -1.25 0.0106 52495 5.88
1381 IPI00410313 KIR3KL3 Killer cell immunoglobulin like receptor 3DL3 132 1.25 0.0144 45470 7.27
1392 IPI00022391 APCS Serum Amyloid P component 181 1.48 0.0223 25837 6.1
1487 IPI00386246 AMPH Amphiphysin I variant CT3, fragment 119 1.24 0.0251 31195 4.23
1796 IPI00007879 SRF Serum response factor 132 1.21 0.0460 51592 7.83
  1. The 45 identified differential spots found among biological replicates of healed versus dehisced wounds (corresponding to t-test < 0.05 and fold change cutoff > 1.2) were identified via LC-MS/MS and yieled 25 unique protein identifications. The table includes spot number, IPI database number, gene name, protein name, MASCOT identification score, fold change and t-test of expression between healed and dehisced wounds, theoretical molecular weight and pI. *Indicates the 9 proteins selected as markers by discriminate analysis. Spot numbers 332, 336, 548, 763, 978, and 1797 were unable to be confidently identified.