Melanoma risk loci as determinants of melanoma recurrence and survival

Table 5 Summary of SNP associations with ulceration status, anatomic site, and tumor thickness

SNP	Locus	Gene	prior GWAS associations		Ulceration status
SNP	Locus	Gene	prior GWAS associations		Crude			Adjusted
				MAF	OR	CI 95%	P	OR	CI 95%	P
rs6001027	22q13.1	PLA2G6	CM; OR = 0.83, p = 1.9e-8	0.35	0.71	0.53-0.92	0.01	0.70	0.53-0.92	0.01
rs2284063	22q13.1	PLA2G6	CM; OR = 0.83, p = 2.4e-9	0.35	0.73	0.56-0.96	0.02	0.73	0.55-0.95	0.02
rs132985	22q13.1	PLA2G6	Nevi; OR = 1.23, p = 2.6e-7	0.44	0.77	0.60-0.99	0.04	0.76	0.59-0.98	0.03
SNP	Locus	Gene	prior GWAS Associations		Anatomic site
SNP	Locus	Gene	prior GWAS Associations		Crude			Adjusted
				MAF	OR	CI 95%	P	OR	CI 95%	P
rs7279297	21q22.3	PRDM15	Tanning; β = -0.12, p = 2.7e-6	0.31	1.26	1.01-1.56	0.03	1.32	1.05-1.66	0.01
rs1028889	1p21.3	-	Tanning; β = 0.10, p = 1.4e-4	0.27	0.81	0.65-0.99	0.04	0.74	0.58-0.92	0.008
rs6497287	15q13.1	HERC2	Eye color; p = 5.05e-15	0.12	0.70	0.53-0.93	0.01	0.70	0.51-0.93	0.01
rs7183877	15q13.1	HERC2	Hair; β = -.29, p = 2.0e-12	0.12	0.72	0.54-0.95	0.02	0.71	0.52-0.95	0.02
			Eye color; p = 6.18e-11
SNP	Locus	Gene	prior GWAS Associations		Thickness
SNP	Locus	Gene	prior GWAS Associations		Crude			Adjusted
				MAF	β Coeff.	SE	P	β Coeff.	SE	P
rs966321	1p36.32	-	Tanning; β = -.14, p = 1.6e-9	0.49	-0.40	0.14	0.005	-0.37	0.14	0.008
rs10861741	12q23.3	BTBD11	Hair; β = .12, p = 1.3e-4	0.15	-0.49	0.20	0.01	-0.47	0.19	0.01

SNP associations with ulceration status and anatomic site were observed using an additive model logistic regression analysis. SNP associations with primary tumor thickness were observed using an additive model linear regression analysis. Both crude (unadjusted by covariates) and adjusted results are shown; adjustments included age at diagnosis, gender, and ethnicity. Associations with melanoma and melanoma related host phenotypes observed in prior GWAS studies are also listed for each SNP.

ISSN: 1479-5876