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Table 4 Subgroup multivariate analysis of SNP associations with recurrence-free survival and overall survival using Cox proportional hazards model

From: Melanoma risk loci as determinants of melanoma recurrence and survival

SNP Subgroup Recurrence-free survival
   HR CI 95% P
rs7538876 Ulceration absent 1.63 1.21-2.10 0.001
  Axial 1.47 1.13-1.91 0.003
  Extremity 1.86 1.28-2.70 0.001
  Thickness <1 mm 3.27 1.62-6.61 0.0009
  SSM 2.3 1.48-3.55 0.0002
rs1805761 Ulceration present 1.57 1.15-2.13 0.004
rs1028889 Extremity 1.73 1.16-2.59 0.007
rs6088520 Thickness 1–4 mm 0.61 0.46-0.80 0.0004
rs9960018 NM 1.91 1.29-2.84 0.001
rs12913832 NM 0.66 0.49-0.88 0.005
SNP Subgroup Overall survival
   HR CI 95% P
rs12750212 Ulceration present 2.89 1.45-5.72 0.002
rs1805761 Ulceration present 1.72 1.17-2.55 0.006
rs9960018 NM 1.97 1.25-3.11 0.003
rs12913832 NM 0.66 0.45-0.97 0.03
  1. Subgroups included tumor thickness (<1 mm, 1-4 mm, >4 mm), ulceration status (present/absent), anatomic site (axial/extremity), and histological type (SSM/NM). SSM = Superficial spreading melanoma, NM = Nodular melanoma. P-values that remain significant after Bonferroni correction (p < 0.0008; based on n = 64 independent tests, see Methods) are bolded. All subgroup associations were stratified by stage and adjustments included age, gender, ethnicity, anatomic site, tumor thickness, ulceration status, histological type, leaving out each dependent variable from the adjustment covariates in each respective subgroup analysis.