Melanoma risk loci as determinants of melanoma recurrence and survival

Table 2 Summary of clinicopathological associations with recurrence-free and overall survival

Variable	Recurrence-free survival		Overall survival
	HR	P	HR	P
Stage
I	Ref		Ref
II	3.06	1.0x10^-9	3.19	1.2x10^-06
III	8.00	<2x10^-16	5.07	2.0x10^-13
IV	192.50	<2x10^-16	52.8	<2x10^-16
Gender
Female	Ref		Ref
Male	1.25	0.093	1.24	0.21
Self-reported ethnicity
Non-AJ	Ref		Ref
AJ	0.85	0.29	0.72	0.13
Sentinel lymph node status
Negative	Ref		Ref
Positive	3.29	<2x10^-16	2.83	1.1x10^-08
Family history of melanoma
No	Ref		Ref
Yes	0.86	0.4	0.66	0.11
Primary tumor ulceration
Absent	Ref		Ref
Present	3.75	<2x10^-16	3.13	5.8x10^-10
Primary tumor mitotic index
None	Ref		Ref
Few	2.13	0.002	1.63	0.092
Moderate	4.27	5.4x10^-10	5.11	2.8x10^-09
Many	7.23	<2x10^-16	2.36	0.004
Primary tumor histological type
SSM	Ref		Ref
ALM	6.60	4.6x10^-11	6.6	9.1x10^-08
DM	3.42	0.0004	2.36	0.056
LMM	2.10	0.12	3.4	0.022
NM	4.48	<2x10^-16	3.68	4.4x10^-09
Other	1.44	0.37	1.72	0.31
Primary tumor anatomic site
Axial	Ref		Ref
Extremity	0.72	0.026	0.66	0.033
Age at pathological diagnosis
	1.01	0.035	1.02	1.20x10^-05
Primary tumor thickness (mm)
	1.11	<2x10^-16	1.1	5.30x10^-11

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