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Table 2 Summary of clinicopathological associations with recurrence-free and overall survival

From: Melanoma risk loci as determinants of melanoma recurrence and survival

Variable Recurrence-free survival Overall survival
  HR P HR P
Stage     
I Ref   Ref  
II 3.06 1.0x10-9 3.19 1.2x10-06
III 8.00 <2x10-16 5.07 2.0x10-13
IV 192.50 <2x10-16 52.8 <2x10-16
Gender     
Female Ref   Ref  
Male 1.25 0.093 1.24 0.21
Self-reported ethnicity     
Non-AJ Ref   Ref  
AJ 0.85 0.29 0.72 0.13
Sentinel lymph node status     
Negative Ref   Ref  
Positive 3.29 <2x10-16 2.83 1.1x10-08
Family history of melanoma     
No Ref   Ref  
Yes 0.86 0.4 0.66 0.11
Primary tumor ulceration     
Absent Ref   Ref  
Present 3.75 <2x10-16 3.13 5.8x10-10
Primary tumor mitotic index     
None Ref   Ref  
Few 2.13 0.002 1.63 0.092
Moderate 4.27 5.4x10-10 5.11 2.8x10-09
Many 7.23 <2x10-16 2.36 0.004
Primary tumor histological type     
SSM Ref   Ref  
ALM 6.60 4.6x10-11 6.6 9.1x10-08
DM 3.42 0.0004 2.36 0.056
LMM 2.10 0.12 3.4 0.022
NM 4.48 <2x10-16 3.68 4.4x10-09
Other 1.44 0.37 1.72 0.31
Primary tumor anatomic site     
Axial Ref   Ref  
Extremity 0.72 0.026 0.66 0.033
Age at pathological diagnosis     
  1.01 0.035 1.02 1.20x10-05
Primary tumor thickness (mm)     
  1.11 <2x10-16 1.1 5.30x10-11