Figure 12

Changes in protein expressions of anti-oxidant biomarkers in kidney at 24 and 72 h after ischemia-reperfusion (IR) procedure (n = 6 at each time for each group). A and B) The protein expression of heme oxygenase (HO)-1 at 24 h (A) and 72 h (B) after acute IR procedure. * vs. other groups with different symbols (*, †, ‡), p < 0.001 at 24 h and 72 h, respectively. C and D) The protein expression of NAD(P)H quinone oxidoreductase (NQO)-1 at 24 h (C) and 72 h (D) after acute IR procedure. * vs. other groups with different symbols (*, †, ‡), p < 0.001 at 24 h and 72 h, respectively. E and F) The protein expression of Glutathione peroxidase (GPx) at 24 h (E) and 72 h (F) after acute IR procedure. * vs. other groups with different symbols (*, †, ‡), p < 0.001 at 24 h and 72 h, respectively. All statistical analyses were with one-way ANOVA followed by Bonferroni multiple comparison post hoc test. Symbols (*, †, ‡) indicate significance at the 0.05 level. SC = sham control; IR = ischemia-reperfusion; Sita = sitagliptin; Ex-4 = extendin-4.