Figure 2
FAK small inhibitor and cell-matrix adhesion. A: Effect of FP-573228 on the adhesion of genetically modified PC-3 cells. a/b/c: cell treated with medium alone; d/e/f: cells treated with FP-573228 (5nM). All three cells responded to the FAK inhibitor FP-573228 by reducing the adhesiveness. The inhibitory effect is particularly strong with PC-3TGase4exp cells. B: Adhesion as calculated using the Rb model. C: The effect of FP-573228 on exogenous TGase-4 induced adhesion in PC-3 control cells. rhTGase-4 significantly increased the adhesiveness which was reverted by FP-573228. D: The effect of FP-573228 on exogenous TGase-4 induced adhesion in CA-HPV-10. * p < 0.05 vs no-treatment control of the same cell; ** p < 0.05 vs wile type and control cells.