Figure 2
From: Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed
In vivo effects of ESOM on tumor growth in CB.17 SCID/SCID mice. Mice were engrafted with Saos-2 cells via s.c. injection in the right flank. At the time of tumor appearance (approximately 7–10 days after injection), mice were left untreated or were pre-treated with 25 mg/kg of ESOM 24 hrs before the i.p. injection of CDP or treated with CDP alone. Tumor size was measured three times per week, and volume was calculated as described in the “Methods” section. The histograms represent mean +/− 95% confidence intervals of tumor weight.