Figure 2

Sources of superoxide anions in mesenteric arteries of morbid obese subjects with insulin resistance (IR-MO). Effects of preincubation with the NADPH oxidase inhibitors, apocynin (100 μmol/l) (A); or VAS2870 (10 μmol/l) (B); the NOS cofactor, tetrahydrobiopterin (BH₄; 10 μmol/l) (C); and the SOD mimetic targeted to the mitochondria, mito-TEMPO (5 μmol/l) (D) on the relaxant response to bradykinin in isolated mesenteric microvessels from IR-MO subjects. Data are expressed as mean±SEM of the percentage of the contraction elicited by K⁺. N= the number of subjects/n= the number of vascular segments. ^*p< 0.001 vs IR-MO by two-factors ANOVA.