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Table 5 Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of colorectal cancer

From: Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer

Colorectal cancer

 

NO. of patients

NKG2D

NKp30

NKp46

Perforin

KIR3DL1

  

%

P

%

P

%

P

%

P

%

P

Histological grade

           

Well/Moderately

20

89.0 ± 3.7

< 0.01 U

39.5 ± 19.3

ns T

56.0 ± 25.8

ns T

83.9 ± 11.6

< 0.05 U

20.1 ± 15.9

ns U

Poorly

12

77.9 ± 13.3

 

47.8 ± 19.2

 

53.6 ± 21.8

 

63.5 ± 22.8

 

18.6 ± 6.6

 

Depth of invasion *

           

Tis/T1/T2/T3

7

88.9 ± 4.3

ns U

57.0 ± 12.4

< 0.05 T

71.4 ± 19.5

< 0.05 T

87.7 ± 13.0

< 0.05 U

20.7 ± 11.1

ns U

T4

25

83.7 ± 10.9

 

38.6 ± 19.2

 

50.5 ± 23.5

 

73.1 ± 19.6

 

19.2 ± 13.8

 

Lymph node metastasis

           

Absent

18

89.3 ± 4.2

< 0.01 U

39.3 ± 20.2

ns U

63.8 ± 24.8

< 0.05 U

86.2 ± 8.8

< 0.01 U

21.2 ± 16.8

ns U

Present

14

79.1 ± 12.4

 

46.9 ± 18.1

 

43.8 ± 18.1

 

63.5 ± 21.5

 

17.4 ± 5.5

 

Blood vessel invasion

           

Absent

25

86.5 ± 7.8

ns U

42.0 ± 20.1

ns U

53.9 ± 24.1

ns U

77.8 ± 18.2

ns U

19.0 ± 14.5

ns U

Present

7

78.9 ± 15.0

 

44.6 ± 17.9

 

59.1 ± 25.2

 

70.7 ± 23.0

 

21.4 ± 6.3

 

Nerve invasion

           

Absent

27

84.0 ± 11.7

ns U

40.9 ± 18.6

ns T

55.7 ± 23.3

ns U

75.8 ± 19.7

ns U

20.8 ± 13.7

ns U

Present

5

84.7 ± 3.1

 

51.8 ± 23.1

 

51.4 ± 30.4

 

78.8 ± 17.8

 

12.7 ± 6.5

 
  1. *According to 2010 American Joint Committee on Cancer (AJCC), Tis, T1, T2, or T3 colorectal cancer invades inside of colorectal serosa or non-peritonealized adjacent colorectal tissue; T4 gastric cancer invades outside of colorectal serosa or adjacent organs. U represents Mann–Whitney U-tests and T represents independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).