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Table 5 Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of colorectal cancer

From: Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer

Colorectal cancer
  NO. of patients NKG2D NKp30 NKp46 Perforin KIR3DL1
   % P % P % P % P % P
Histological grade            
Well/Moderately 20 89.0 ± 3.7 < 0.01 U 39.5 ± 19.3 ns T 56.0 ± 25.8 ns T 83.9 ± 11.6 < 0.05 U 20.1 ± 15.9 ns U
Poorly 12 77.9 ± 13.3   47.8 ± 19.2   53.6 ± 21.8   63.5 ± 22.8   18.6 ± 6.6  
Depth of invasion *            
Tis/T1/T2/T3 7 88.9 ± 4.3 ns U 57.0 ± 12.4 < 0.05 T 71.4 ± 19.5 < 0.05 T 87.7 ± 13.0 < 0.05 U 20.7 ± 11.1 ns U
T4 25 83.7 ± 10.9   38.6 ± 19.2   50.5 ± 23.5   73.1 ± 19.6   19.2 ± 13.8  
Lymph node metastasis            
Absent 18 89.3 ± 4.2 < 0.01 U 39.3 ± 20.2 ns U 63.8 ± 24.8 < 0.05 U 86.2 ± 8.8 < 0.01 U 21.2 ± 16.8 ns U
Present 14 79.1 ± 12.4   46.9 ± 18.1   43.8 ± 18.1   63.5 ± 21.5   17.4 ± 5.5  
Blood vessel invasion            
Absent 25 86.5 ± 7.8 ns U 42.0 ± 20.1 ns U 53.9 ± 24.1 ns U 77.8 ± 18.2 ns U 19.0 ± 14.5 ns U
Present 7 78.9 ± 15.0   44.6 ± 17.9   59.1 ± 25.2   70.7 ± 23.0   21.4 ± 6.3  
Nerve invasion            
Absent 27 84.0 ± 11.7 ns U 40.9 ± 18.6 ns T 55.7 ± 23.3 ns U 75.8 ± 19.7 ns U 20.8 ± 13.7 ns U
Present 5 84.7 ± 3.1   51.8 ± 23.1   51.4 ± 30.4   78.8 ± 17.8   12.7 ± 6.5  
  1. *According to 2010 American Joint Committee on Cancer (AJCC), Tis, T1, T2, or T3 colorectal cancer invades inside of colorectal serosa or non-peritonealized adjacent colorectal tissue; T4 gastric cancer invades outside of colorectal serosa or adjacent organs. U represents Mann–Whitney U-tests and T represents independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).