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Table 3 Association between the percentage of surface receptors and cytotoxic granules positive NK cells and the clinicopathological features of pancreatic cancer

From: Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer

Pancreatic cancer
  NO. of patients NKG2D NKp30 NKp46 Perforin KIR3DL1
   % P % P % P % P % P
Distant metastasis            
Absent 20 82.6 ± 9.5 ns T 44.2 ± 19.3 ns T 53.8 ± 23.4 ns T 80.5 ± 16.8 ns U 20.6 ± 12.1 ns U
Present 11 85.5 ± 6.4   50.7 ± 22.1   60.9 ± 20.2   78.7 ± 15.0   18.4 ± 10.3  
Non-metastatic Pancreatic cancer
  NO. of patients NKG2D NKp30 NKp46 Perforin KIR3DL1
   % P % P % P % P % P
Histological grade            
Well/Moderately 9 85.4 ± 8.9 ns T 46.2 ± 27.1 ns T 71.4 ± 17.4 < 0.01 U 85.3 ± 8.5 ns U 23.2 ± 13.6 ns U
Poorly 11 79.6 ± 9.1   40.6 ± 12.4   39.5 ± 17.1   76.5 ± 21.0   18.6 ± 10.8  
Depth of invasion *            
Tis/T1/T2 11 84.3 ± 7.6 ns T 41.2 ± 18.2 ns T 54.4 ± 22.6 ns T 75.2 ± 19.1 ns U 18.7 ± 10.4 ns T
T3 9 79.7 ± 10.9   46.0 ± 22.9   53.2 ± 25.6   86.9 ± 11.6   23.0 ± 14.1  
Lymph node metastasis            
Absent 6 89.9 ± 5.6 < 0.05 T 58.1 ± 19.0 < 0.05 T 60.9 ± 22.6 ns T 80.9 ± 21.7 ns U 27.0 ± 15.5 ns T
Present 14 78.9 ± 8.6   37.8 ± 17.7   50.8 ± 23.8   80.3 ± 15.3   17.9 ± 9.7  
Blood vessel invasion            
Absent 13 86.7 ± 6.7 < 0.01 T 40.3 ± 22.7 ns U 54.7 ± 24.9 ns U 86.2 ± 12.9 < 0.05 U 21.9 ± 14.4 ns U
Present 7 73.9 ± 7.6   48.4 ± 13.7   52.2 ± 22.1   69.9 ± 19.1   18.3 ± 6.1  
Nerve invasion            
Absent 6 86.9 ± 5.7 ns T 36.2 ± 22.6 ns U 60.5 ± 27.6 ns U 78.1 ± 16.1 ns U 15.9 ± 5.6 ns T
Present 14 80.2 ± 9.9   45.9 ± 19.0   51.0 ± 21.8   81.5 ± 17.6   22.7 ± 13.6  
  1. *According to 2010 American Joint Committee on Cancer (AJCC), T4 pancreatic cancer invades celiac artery or superior mesenteric artery, and is unresectable, so T4 is not enrolled in depth of invasion for non-metastatic pancreatic cancer. Tis, T1, or T2 pancreatic cancer invades inside of the pancreas; T3 pancreatic primary cancer invades outside of the pancreas. U represented Mann–Whitney U-tests and T represented independent t-tests. Data were expressed as means ± standard deviations (Mean ± SD).