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Table 2 Laboratory data of the SLE patients and control subjects

From: The association among leukocyte apoptosis, autoantibodies and disease severity in systemic lupus erythematosus

  SLE patients
(n = 23)
SJS patients
(n = 9)
Healthy controls
(n = 20)
p value
White blood cells (×103/ml) 6.73 ± 2.5 6.47 ± 1.97 5.68 ± 1.89 0.442
% granulocyte 69.49 ± 13.19 65.93 ± 10.22 61.6 ± 12.76 0.341
% lymphocyte 22.81 ± 11.65 25.33 ± 9.15 31.01 ± 10.85 0.232
% monocyte 5.57 ± 3.00 6.19 ± 2.44 5.63 ± 1.74 0.873
Hemoglobulin (mg/dL) 11.73 ± 1.73 12.38 ± 0.99 14.06 ± 1.86 0.003α
Platelet counts (×104/ml) 22.13 ± 8.49 23.67 ± 5.39 22.26 ± 6.19 0.851
Autoantibodies titers     
a-dsdna 18 (1.7, 70.0) ND ND ND
a-ro 0.5 (0.1, 240) 84.75 (0.3, 217.5) ND 0.725
a-ro52 0.3 (0.1, 32) ND ND ND
a-ro60 0.9 (0, 300) ND ND ND
a-la 0.2 (0, 3.3) 0.2 (0.1, 4.45) ND 0.896
a-mi2 0.1 (0, 0.2) ND ND ND
Apoptosis tested by flow cytometry?     
Leukocyte apoptosis (%)     
 Annexin V (%) 15.3 (8.9-18.2) 9.87 (8.29-12.50) 10.9 (8.8-13.4) 0.005β
 APO2.7 (%) 1.3 (0.9-2.2) 1.10(0.70-1.57) 0.7 (0.5-0.9) 0.001γ
 Annexin V + 7AAD (%) 7.1 (3.8-11.8) 6.58(2.80-10.10) 3.2 (2.6-4.5) 0.011δ
Neutrophil apoptosis (%)     
 Annexin V (%) 21.6 (11.7-28.8) 9.15 (7.80-15.76) 13.9 (10.3-18.0) 0.010ϵ
 APO2.7 (%) 0.6 (0.4-1.3) 0.79(0.40-1.05) 0.5 (0.4-0.6) 0.001ζ
 Annexin V + 7AAD (%) 10.7 (3.1-22.8) 6.93(1.97-20.60) 3.9 (2.2-5.5) 0.026η
Lymphocyte apoptosis (%)     
 Annexin V (%) 8.4 (4.9-12.1) 6.10 (5.11-8.23) 4.8 (3.8-6.7) 0.009θ
 APO2.7 (%) 0.7 (0.5-1.0) 0.46(0.43-0.78) 0.3 (0.2-0.4) 0.008κ
 Annexin V + 7AAD (%) 2.1 (1.2-3.6) 1.46(0.67-2.92) 1.5 (0.9-2.1) 0.101
Monocyte apoptosis (%)     
 Annexin V (%) 19.6 (13.5-27.3) 13.83 (11.42-15.38) 17.4 (12.4-21.6) 0.032λ
 APO2.7 (%) 3.0 (2.5-6.8) 1.94 (1.48-3.27) 1.8 (1.1-2.7) 0.088
 Annexin V + 7AAD (%) 10.4 (5.3-17.8) 7.63 (3.34-15.36) 4.6 (3.3-6.0) 0.024μ
  1. Abbreviations: SLE Systemic lupus erythematosus, SJS Sjogren’s syndrome, WBC White blood cells or leukocytes, 7-AAD 7-amino-actinomycin D, SD Standard deviation, IQR Inter-quartile range, A-dsdna Anti-dsDNA, A-ro Anti-Ro52/60, A-ro52 Anti-Ro 52 kDa, A-ro60 Anti-Ro 60 kDa, A-la Anti-La, ND Not done.
  2. ϮFigures are median (IQR) or number (%).
  3. Results of Bonferroni multiple comparisons for post hoc test (SLE vs. control, SLE vs. SJS, or SJS vs. control).
  4. α, SLE vs. control = 0.002; β, SLE vs. control = 0.014, SLE vs. SJS = 0.029; γ, SLE vs. control = 0.001; δ, SLE vs. control = 0.009; ϵ, SLE vs. control = 0.005, SLE vs. SJS = 0.004; ζ, SLE vs. control = 0.041; η, SLE vs. control = 0.021; θ, SLE vs. control = 0.008; κ, SLE vs. control = 0.007; λ, SLE vs. SJS = 0.036; μ, SLE vs. control = 0.026.