Skip to main content

Table 2 Laboratory data of the SLE patients and control subjects

From: The association among leukocyte apoptosis, autoantibodies and disease severity in systemic lupus erythematosus

 

SLE patients

(n = 23)

SJS patients

(n = 9)

Healthy controls

(n = 20)

p value

White blood cells (×103/ml)

6.73 ± 2.5

6.47 ± 1.97

5.68 ± 1.89

0.442

% granulocyte

69.49 ± 13.19

65.93 ± 10.22

61.6 ± 12.76

0.341

% lymphocyte

22.81 ± 11.65

25.33 ± 9.15

31.01 ± 10.85

0.232

% monocyte

5.57 ± 3.00

6.19 ± 2.44

5.63 ± 1.74

0.873

Hemoglobulin (mg/dL)

11.73 ± 1.73

12.38 ± 0.99

14.06 ± 1.86

0.003α

Platelet counts (×104/ml)

22.13 ± 8.49

23.67 ± 5.39

22.26 ± 6.19

0.851

Autoantibodies titers

    

a-dsdna

18 (1.7, 70.0)

ND

ND

ND

a-ro

0.5 (0.1, 240)

84.75 (0.3, 217.5)

ND

0.725

a-ro52

0.3 (0.1, 32)

ND

ND

ND

a-ro60

0.9 (0, 300)

ND

ND

ND

a-la

0.2 (0, 3.3)

0.2 (0.1, 4.45)

ND

0.896

a-mi2

0.1 (0, 0.2)

ND

ND

ND

Apoptosis tested by flow cytometry?

    

Leukocyte apoptosis (%)

    

 Annexin V (%)

15.3 (8.9-18.2)

9.87 (8.29-12.50)

10.9 (8.8-13.4)

0.005β

 APO2.7 (%)

1.3 (0.9-2.2)

1.10(0.70-1.57)

0.7 (0.5-0.9)

0.001γ

 Annexin V + 7AAD (%)

7.1 (3.8-11.8)

6.58(2.80-10.10)

3.2 (2.6-4.5)

0.011δ

Neutrophil apoptosis (%)

    

 Annexin V (%)

21.6 (11.7-28.8)

9.15 (7.80-15.76)

13.9 (10.3-18.0)

0.010ϵ

 APO2.7 (%)

0.6 (0.4-1.3)

0.79(0.40-1.05)

0.5 (0.4-0.6)

0.001ζ

 Annexin V + 7AAD (%)

10.7 (3.1-22.8)

6.93(1.97-20.60)

3.9 (2.2-5.5)

0.026η

Lymphocyte apoptosis (%)

    

 Annexin V (%)

8.4 (4.9-12.1)

6.10 (5.11-8.23)

4.8 (3.8-6.7)

0.009θ

 APO2.7 (%)

0.7 (0.5-1.0)

0.46(0.43-0.78)

0.3 (0.2-0.4)

0.008κ

 Annexin V + 7AAD (%)

2.1 (1.2-3.6)

1.46(0.67-2.92)

1.5 (0.9-2.1)

0.101

Monocyte apoptosis (%)

    

 Annexin V (%)

19.6 (13.5-27.3)

13.83 (11.42-15.38)

17.4 (12.4-21.6)

0.032λ

 APO2.7 (%)

3.0 (2.5-6.8)

1.94 (1.48-3.27)

1.8 (1.1-2.7)

0.088

 Annexin V + 7AAD (%)

10.4 (5.3-17.8)

7.63 (3.34-15.36)

4.6 (3.3-6.0)

0.024μ

  1. Abbreviations: SLE Systemic lupus erythematosus, SJS Sjogren’s syndrome, WBC White blood cells or leukocytes, 7-AAD 7-amino-actinomycin D, SD Standard deviation, IQR Inter-quartile range, A-dsdna Anti-dsDNA, A-ro Anti-Ro52/60, A-ro52 Anti-Ro 52 kDa, A-ro60 Anti-Ro 60 kDa, A-la Anti-La, ND Not done.
  2. ϮFigures are median (IQR) or number (%).
  3. Results of Bonferroni multiple comparisons for post hoc test (SLE vs. control, SLE vs. SJS, or SJS vs. control).
  4. α, SLE vs. control = 0.002; β, SLE vs. control = 0.014, SLE vs. SJS = 0.029; γ, SLE vs. control = 0.001; δ, SLE vs. control = 0.009; ϵ, SLE vs. control = 0.005, SLE vs. SJS = 0.004; ζ, SLE vs. control = 0.041; η, SLE vs. control = 0.021; θ, SLE vs. control = 0.008; κ, SLE vs. control = 0.007; λ, SLE vs. SJS = 0.036; μ, SLE vs. control = 0.026.
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us