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Table 3 Differentially released proteins by CEA specimens

From: Secreted proteins from carotid endarterectomy: an untargeted approach to disclose molecular clues of plaque progression

Localization

Protein name (1)

Gene name

Role in atherosclerosis (2)

P/DS (3)

P value(4)

Plasma(5)

Cellular

Alpha-actinin 1

ACTN1

Focal adhesion

â–¼

6.70E-04

☑

Integrin-linked protein kinase

ILK

Focal adhesion

â–¼

1.10E-04

☑

Actin-related protein 2/3

ARPC3

Focal adhesion

â–¼

1.20E-04

☑

Filamin A

FLNA

Focal adhesion

â–¼

1.35E-05

☑

PDZ and LIM domain protein 1

PDLI1

Focal adhesion

â–¼

1.34E-03

☑

PDZ and LIM domain protein 7

PDLI7

Focal adhesion

â–¼

5.70E-04

☑

Vimentin

VIM

Focal adhesion

â–¼

2.02E-03

☑

Vinculin

VCL

Focal adhesion [12]

â–¼

2.80E-04

☑

Cysteine-rich protein 2

CRIP2

SMC differentiation [22]

â–¼

1.10E-04

 

Calponin 1

CNN1

SMC differentiation

â–¼

1.90E-04

 

Calponin 2

CNN2

SMC differentiation

â–¼

2.57E-03

☑

Calponin 3

CNN3

SMC differentiation

â–¼

1.10E-04

 

Transgelin

TAGL

SMC differentiation

â–¼

3.00E-03

 

Tropomyosin-1 alpha

TPM1

SMC differentiation

â–¼

2.63E-03

☑

Tropomyosin beta

TPM2

SMC differentiation

â–¼

1.14E-03

☑

Smoothelin

SMOO

SMC differentiation and plaque stability [23]

â–²

3.40E-04

☑

 

Vascular cell adhesion protein 1 (VCAM-1)

VCAM1

Monocyte recruitment

â–¼

1.39E-02

☑

Extracellular matrix (ECM)

Collagen alpha 1 (III)

COL3A1

Plaque stability

â–²

1.70E-04

 

Collagen alpha 1 (VI)

COL6A1

Plaque stability

â–²

2.40E-04

 

Collagen alpha 1 (XIV)

COL14A1

Atherogenesis

â–²

1.05E-03

 

Collagen alpha 1 (XVI)

COL16A1

Atherogenesis

â–²

2.07E-03

 

Versican

VCAN

Atherogenesis [24]

â–²

1.45E-05

 

Lumican

LUM

Plaque rupture [24]

â–²

4.07E-02

☑

Fibulin 2

FBLN2

Cell migration [25]

â–²

9.00E-03

 

Emilin 1

EMILIN1

Elastic lamellae integrity [26]

â–²

1.82E-03

☑

Periostin

POSTN

Angiogenesis

â–²

2.07E-03

 

Thrombospondin-1

THBS1

Angiogenesis [27]

â–²

1.71E-02

☑

Vitamin D binding protein

GC

Acute events [28, 29]

â–²

1.93E-02

☑

Apolipoprotein A-II

APOA2

Lipid transport

â–²

1.28E-03

☑

Apolipoprotein D

APOD

Lipid transport

â–²

3.11E-05

☑

 

Aggrecan

ACAN

Lipoprotein retention

â–²

1.51E-05

 
  1. (1) Protein name is reported according with SwissProt 2011 database. (2) Role in atherosclerosis is referred to data reported on the recent literature (3) â–¼: down released in P compared with DS; â–²: up released in P vs DS. (4) P values were generated using Marker View software. (5) Their presence in plasma was showed according to Human Protein Reference database (http://www.hprd.org).
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Journal of Translational Medicine

ISSN: 1479-5876

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