Variable | Cases (n / %) | RECK expression (number of cases / %) | P value* | ||||
---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | ||||
Age | ≤60 years | 197 (49.9) | 161 (81.7) | 27 (13.7) | 8 (4.1) | 1 (0.5) | 0.580 |
>60 years | 198 (50.1) | 164 (82.8) | 22 (11.1) | 5 (2.5) | 7 (3.5) | ||
Sex | male | 264 (66.8) | 212 (80.3) | 36 (13.6) | 11 (4.2) | 5 (1.9) | 0.234 |
female | 131 (33.2) | 113 (86.3) | 13 (9.9) | 2 (1.5) | 3 (2.3) | ||
pT status | pT1-2 | 265 (67.1) | 216 (81.5) | 32 (12.1) | 10 (3.8) | 7 (2.6) | 0.250 |
pT3-4 | 130 (32.9) | 109 (83.8) | 17 (13.1) | 3 (2.3) | 1 (0.8) | ||
Fuhrman grade | 1-2 | 348 (88.1) | 285 (81.9) | 43 (12.4) | 12 (3.4) | 8 (2.3) | 0.338 |
3-4 | 47 (11.9) | 40 (85.1) | 6 (12.8) | 1 (2.1) | 0 (0.0) | ||
Nodal status** | pN0 | 214 (89.9) | 182 (85.0) | 25 (11.7) | 5 (2.3) | 2 (0.9) | 0.878 |
pN+ | 24 (10.1) | 20 (83.3) | 3 (12.5) | 1 (4.2) | 0 (0.0) | ||
Metastases*** | M0 | 338 (90.6) | 278 (82.2) | 41 (12.1) | 12 (3.6) | 7 (2.1) | 0.300 |
M1 | 35 (9.4) | 31 (88.6) | 3 (8.6) | 1 (2.9) | 0 (0.0) | ||
Margin status**** | R0 | 357 (94.4) | 291 (81.5) | 46 (12.9) | 12 (3.4) | 8 (2.2) | 0.603 |
R+ | 21 (5.6) | 18 (85.7) | 2 (9.5) | 1 (4.8) | 0 (0.0) | ||
Tumor subtype | |||||||
Clear cell RCC | 322 (81.5) | 291 (90.4) | 27 (8.4) | 3 (0.9) | 1 (0.3) | <0.001 | |
Papillary RCC | 43 (10.9) | 23 (53.5) | 11 (25.6) | 8 (18.6) | 1 (2.3) | ||
Chromophobe RCC | 22 (5.6) | 10 (45.5) | 7 (31.8) | 1 (4.5) | 4 (18.2) | ||
Oncocytoma | 8 (2.0) | 1 (12.5) | 4 (50.0) | 1 (12.5) | 2 (25.0) | ||
EMMPRIN expression (number of cases / %) | |||||||
0 | 1 | 2 | 3 | ||||
Age | ≤60 years | 196 (49.7) | 7 (3.6) | 57 (29.1) | 70 (35.7) | 62 (31.6) | 0.479 |
>60 years | 198 (50.3) | 8 (4.0) | 54 (27.3) | 87 (43.9) | 49 (24.7) | ||
Sex | male | 263 (66.8) | 13 (4.9) | 70 (26.6) | 102 (38.8) | 78 (29.7) | 0.797 |
Female | 131 (33.2) | 2 (1.5) | 41 (31.3) | 55 (42.0) | 33 (25.2) | ||
pT status | pT1-2 | 265 (67.3) | 14 (5.3) | 86 (32.5) | 112 (42.3) | 53 (20.0) | <0.001 |
pT3-4 | 129 (32.7) | 1 (0.8) | 25 (19.4) | 45 (34.9) | 58 (45.0) | ||
Fuhrman grade | 1-2 | 347 (88.1) | 15 (4.3) | 109 (31.4) | 141 (40.6) | 82 (23.6) | <0.001 |
3-4 | 47 (11.9) | 0 (0.0) | 2 (4.3) | 16 (34.0) | 29 (61.7) | ||
Nodal status** | pN0 | 213 (89.9) | 6 (2.8) | 63 (29.6) | 78 (36.6) | 66 (31.0) | 0.003 |
pN+ | 24 (10.1) | 1 (4.2) | 1 (4.2) | 7 (29.2) | 15 (62.5) | ||
Metastases*** | M0 | 337 (90.6) | 15 (4.5) | 101 (30.0) | 138 (40.9) | 83 (24.6) | <0.001 |
M1 | 35 (9.4) | 0 (0.0) | 6 (17.1) | 9 (25.7) | 20 (57.1) | ||
Margin status**** | R0 | 356 (94.4) | 15 (4.2) | 105 (29.5) | 145 (40.7) | 91 (25.6) | 0.004 |
R+ | 21 (5.6) | 0 (0.0) | 3 (14.3) | 6 (28.6) | 12 (57.1) | ||
Tumor subtype | |||||||
Clear cell RCC | 322 (81.7) | 9 (2.8) | 91 (28.3) | 128 (39.8) | 94 (29.2) | 0.813 | |
Papillary RCC | 42 (10.7) | 6 (14.3) | 14 (33.3) | 16 (38.1) | 6 (14.3) | ||
Chromophobe RCC | 22 (5.6) | 0 (0.0) | 5 (22.7) | 9 (40.9) | 8 (36.4) | ||
Oncocytoma | 8 (2.0) | 0 (0.0) | 1 (12.5) | 4 (50.0) | 3 (37.5) |