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Table 2 Association of the combined expression of Cav-1 and pERK with conventional histological parameters in RCC

From: Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease

  Cav-1 (n = 165) p-ERK1/2 (n = 164) Cav-1/pERK1/2 (n = 158)
  - + - + All other Tumours +/+
Grade 1 & 2 69 47 75 43 93 19
Grade 3 & 4 25 24 29 17 36 10
   P = 0.390   P = 0.951   P = 0.091
Tumour size <7 cm 49 29 55 24 64 10
>7 cm 45 42 49 36 65 19
   P = 0.151   P = 0.112   P = 0.142
Vascular Invasion (-ve) 66 33 71 30 85 10
(+ve) 28 38 33 30 44 19
   P = 0.002*   P = 0.021*   P = 0.002*
Capsular Invasion (-ve) 83 55 90 47 109 22
(+ve) 11 16 14 13 20 7
   P = 0.063   P = 0.172   P = 0.267
Tumour Stage 1 44 21 50 17 55 7
Stage 2 31 14 28 15 38 4
Stage 3 & 4 19 36 26 28 36 18
   P = 0.0001*   P = 0.011*   P = 0.002*
Non- papillary 76 67 84 58 109 28
Papillary 18 4 20 2 20 1
   P = 0.011*   P = 0.004*   P = 0.084
  1. * Indicates that statistical significance achieved to at least P < 0.05 with actual P value indicated in the Table itself.