Figure 4

Effect of Cav-1 knockdown on signalling molecules in RCC cell lines. (4A) - Secretion of VEGF-A in RCC cells. Data is expressed as mean ± SD (n = 3) and is representative of two independent experiments; (4B) - Activity of AKT/mTOR and ERK signalling pathways and expression of the cell cycle regulators cyclinD1 and c-myc in RCC cell lines as a function of Cav-1 siRNA-mediated knockdown. Western blot is representative of at least four independent experiments.