Notch1 signaling improves cardiac function in isolated rat hearts. A-D, Measurement of heart rate (HR), left ventricular developed pressure (LVDP) and maximal (dP/dtmax) and minimal (dP/dtmin) value of the first derivative of left ventricular pressure. Data were shown as the percentage of the values recorded at 1 min before ischemia. Data were presented as mean±SD, n=6. a: I/R+N1ICD vs I/R; P<0.05; b: IPC vs I/R, P<0.05; c: IPC vs IPC+shRNA, P<0.05; d: IPost vs I/R, P<0.05; e: IPost vs IPost+shRNA, P<0.05.