Table 3 Summary of MHC class I molecules expressed/secreted on/by macrophages/tumor associated macrophages, their related ligands on immune cells and the function of their interaction
From: HLA-dependent tumour development: a role for tumour associate macrophages?
MHC (macrophage/TAMs) | RECEPTOR (immune cells) | FUNCTION | References |
|---|---|---|---|
Membrane HLA-A-B-C | ILT2 on NK cells | - Negative regulation of INFgamma secretion | - Morel E. 2008 [133] |
ILT2 on T cells | - Negative regulation of T cell function | - Dietrich J. 2001 [136] | |
Membrane HLA-A-B | KIR3DL1/2 on NK cells and effector T cells | - Inhibition of cytolitic function | - Anfossi N. 2004 [93] |
- Long E.O. 2008 [94] | |||
Membrane HLA-C | KIR2DL1/2/3 on NK cells and effector T cell | - Inhibition of cytolitic function | - Colonna M. 1993 [92] |
- Falk C.S. 1995 [132] | |||
Membrane HLA-G1 | Â | - HLA-G1 is acquired through trogocytosis by CD4+ and CD8+ T cells resulting their temporarily reversion to regulatory T cells | - LeMaoult J. 2007 [143] |
Soluble HLA-G5 | ILT2 and ILT4 on myeloid APC | - secretion of the cytokine TGF-beta1 that contributes to T cells peripheral tolerance | - McIntire R.H. 2004 [122] |
- Turning down myeloid APC activation level | - Jones D.C. 2011 [79] | ||
KIR2DL4 on CD56bright NK cells | - Secretion of pro-angiogenic cytokines and chemokines | - Rajagopalan S. 1999 [147] | |
- Rajagopalan S. 2012 [96] | |||
CD8 on activated CD8+ T cells and CD8+ NK cells | - Fas/Fas ligand mediated cell death | - Contini P. 2003 [145] | |
- Puppo F. 2002 [146] | |||
- LeMaoult J. 2004 [144] | |||
Membrane HLA-E | CD94/NKG2A on NK cells and cytotoxic T cells | - Production of immune-suppressive cytokines (IL-10 and TGF-beta1) by NK cells | - Jinushi M. 2004 [148] |
- Inhibition of cytolitic function | - Braud V.M. 1998 [46] | ||
- Borrego F. 1998 [102] |