Table 2 Summary of MHC class I molecules expressed/released on/by tumor cells, the related ligands on myeloid cells and the function of their interaction
From: HLA-dependent tumour development: a role for tumour associate macrophages?
MHC (tumor cells) | RECEPTOR (myeloid cells) | FUNCTION | References |
|---|---|---|---|
Membrane HLA-G1 and soluble HLA-G5 | ILT2 and ILT4 on macrophages/TAMs | - Up-regulation of LILRB receptor on macrophages/TAMs | - LeMaoult J., 2005 [130] |
| Â | Â | - Turning-down macrophage activation level | - Jones D.C., 2011 [79] |
Membrane HLA-A-B-C | ILT2 and ILT4 on macrophages/TAMs | - Turning-down macrophage activation level | - Jones D.C., 2011 [79] |
| Â | LILRA1 and LILRA3 on macrophages/TAMs | - Stimulation of the alternative macrophage differentation | - Lee D.J., 2007 [89] |
Soluble HLA-G5 | ILT2 and ILT4 on macrophages/TAMs | - Secretion of TGFbeta1 resulting in blood monocytes recruitment and suppression of their cytotoxic function | - McIntire R.H., 2004 [122] |
- Ashcroft G.S., 1999 [123] | |||
| Â | ILT2 on MDSC | -Expansion of MDSC with enhanced suppressive activity | - Zhang W., 2008 [124] |
| Â | Â | -Secretion of Th2 cytokines able to skew the alternative macrophage differentation | - Agaugue S., 2011 [125] |
| Â | ILT4 on monocytes | - Inhibition of maturation of monocyte-derived APC | - Ristich V., 2005 [129] |
| Â | Â | - Development of tolerogenic APC | Â |