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Table 3 Antibody responses in patients vaccinated with 100 μg or 200 μg of CHP-NY-ESO-1

From: Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients

100 μg

200 μg

pt No.

Vaccination cycle

Baseline (dilution titer)

Antibody response (cycle*)

pt No.

Vaccination cycle

Baseline (dilution titer)

Antibody response (cycle*)

100-01

9

negative

responded(4)

200-01

15

negative

responded(2)

100-02

3

negative

no response**

200-02

9

negative

responded(2)

100-03

3

negative

no response**

200-03

8

positive (x1,600)

responded(5)

100-04

7

negative

no response

200-04

21

negative

responded(2)

100-05

2

negative

no response

200-05

3

negative

responded(2)

100-06

16

positive (x6,400)

responded(1)

200-06

10

positive (x400)

responded(1)

100-07

9

positive (x25,600)

no response

200-07

3

positive (x25,600)

responded(2)**

100-08

10

negative

responded(1)

200-08

11

positive (x400)

responded(1)

100-09

5

negative

no response

200-09

18

positive (x400)

responded(3)

100-10

27

positive (x400)

responded(3)

200-10

11

positive (x400)

responded(2)

100-11

8

negative

responded(2)

200-11

3

positive (x400)

responded(2)

100-12

8

negative

responded(2)

200-12

9

negative

responded(1)

100-13

26

negative

responded(2)

    

antibody response rate

53.8%***

100%***

  1. *vaccine cycles with which antibody responses appeared. **antibody responses assayed after two vaccinations.***p = 0.015(Fisher’s exact test).