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Table 3 Genetic background of GC with PTEN loss

From: The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere

Sample ID

PTEN IHC staining results

PIK3CA mutation status

BRAF mutation status

KRAS mutation status

802204

(-)

Wild type

Wild type

Wild type

1007947

(-)

Wild type

V600E

Wild type

44256

(-)

Wild type

Wild type

Wild type

34711

(-)

Wild type

Wild type

n/a

608902

(-)

Wild type

Wild type

Wild type

60077

(-)

Wild type

Wild type

Wild type

606186

(-)

Wild type

Wild type

n/a

803776

(-)

Wild type

Wild type

Wild type

1007953

(-)

Wild type

Wild type

Wild type

708053

(-)

Wild type

Wild type

Wild type

708025

(-)

Wild type

Wild type

n/a

16627

(-)

Wild type

Wild type

n/a

505496

(-)

Wild type

Wild type

n/a

508745

(-)

Wild type

Wild type

Wild type

600460

(+)

E542K/E545D*

Wild type

n/a

802664

(+)

Wild type

Wild type

G12D*

  1. *The PI3KCA and KRAS mutations were mutually exclusive from PTEN loss.