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Table 3 Genetic background of GC with PTEN loss

From: The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere

Sample ID PTEN IHC staining results PIK3CA mutation status BRAF mutation status KRAS mutation status
802204 (-) Wild type Wild type Wild type
1007947 (-) Wild type V600E Wild type
44256 (-) Wild type Wild type Wild type
34711 (-) Wild type Wild type n/a
608902 (-) Wild type Wild type Wild type
60077 (-) Wild type Wild type Wild type
606186 (-) Wild type Wild type n/a
803776 (-) Wild type Wild type Wild type
1007953 (-) Wild type Wild type Wild type
708053 (-) Wild type Wild type Wild type
708025 (-) Wild type Wild type n/a
16627 (-) Wild type Wild type n/a
505496 (-) Wild type Wild type n/a
508745 (-) Wild type Wild type Wild type
600460 (+) E542K/E545D* Wild type n/a
802664 (+) Wild type Wild type G12D*
  1. *The PI3KCA and KRAS mutations were mutually exclusive from PTEN loss.