Table 1 AZD5363 inhibits proliferation of a subset of GC cell lines in vitro
Cell line | Genetic background |  | GI50 (μmol/L) |
|---|---|---|---|
PIK3CA | PTEN | ||
HGC27 | E542K | LOSS | 0.445 |
IM95m | E452K | WT | 0.510 |
AGS | E453K | WT | 0.552 |
NCI-N87 | WT | WT | 1.037 |
23132/87 | WT | WT | 1.671 |
MKN1 | E545K | WT | 2.421 |
SNU-620 | WT | WT | 3.384 |
SNU-638 | WT | WT | 4.523 |
SNU-1 | WT | WT | 5.258 |
SNU-601 | WT | WT | 5.938 |
SNU-668 | WT | WT | 6.003 |
HS746T | WT | WT | 6.084 |
KATO III | WT | WT | 7.267 |
SNU-484 | WT | WT | 7.392 |
SNU-16 | WT | WT | 11.097 |
OCUM-1 | WT | WT | 14.515 |
NUGC-3 | WT | WT | 21.873 |
AZ521 | WT | WT | 25.448 |
SNU-216 | WT | WT | 30.000 |
NUGC-4 | WT | WT | 30.000 |
SNU-5 | WT | WT | 30.000 |
GTL-16 | WT | WT | 30.000 |
MKN74 | WT | WT | 30.000 |
PAMC82 | WT | WT | 30.000 |