Figure 2

AZD5363 treatment results in significant inhibition in PDGCX mouse models. (A). Activation of AKT signaling pathway in SGC100 and SGC020 PDGCX models. The basal levels of phosphor AKT (S473) and phosphor S6 (S235/236) in PDGCX tumors were measured by Western blot analysis. (B). Anti-tumor efficacy of AZD5363 monotherapy in SGC100 PDGCX model. AZD5363 was administered by oral gavage twice (bid) daily to nu/nu mice bearing established PDGCX SGC100 model with PI3KCA mutant tumors at 150 mg/kg single agent. Tumor volumes were monitored and plotted against time. (C) Anti-tumor efficacy of AZD5363 in combination with Taxotere in PDGCX SGC020 model. AZD5363 was administered by oral gavage twice (bid) daily to nu/nu mice bearing established PDGCX SGC020 model with PTEN null tumors at 150 mg/kg in combination with Taxotere at 5 mg/kg weekly. Tumor volumes were monitored and plotted against time.