Parameter | Description | Estimate | %RSE | Bootstrap median (95% CI)a |
---|---|---|---|---|
Pharmacokinetics | ||||
CL/F (L/h) | Apparent clearance | 12.2 | 7.39 | 12.5 (4.9~14.9) |
V/F (L) | Apparent volume of distribution | 691 | 6.54 | 712 (324~980) |
D2 (h) | Duration of zero-order absorption | 20.2 | 7.08 | 19.9 (16.6~23.0) |
KA (h-1) | Absorption rate constant of first-order absorption | 0.00653 | 16.23 | 0.00721 (0.0010~0.1715) |
ALAG (h) | Lag time to the initiation of first-order absorption | 85.7 | 3.92 | 88.1 (80.9~108.0) |
RFb | Alternate variable for relative fraction absorbed in zero-order absorption process | 0.185 | 55.68 | 0.24 (-1.17~0.94) |
ωCL (%) | Between subject variability of CL | 26.1 | 35.1 | 24.5 (14.4~32.7) |
ωV (%) | Between subject variability of V | 23.8 | 58.0 | 23.7 (0.4~37.6) |
ωD2 (%) | Between subject variability of D2 | 35.7 | 27.1 | 34.8 (23.0~49.4) |
ωRF (%) | Between subject variability of RF | 34.7 | 64.1 | 32.1 (0.3~54.2) |
ωka (%) | Between subject variability of KA | 77.0 | 37.1 | 59.5 (0.7~95.4) |
σadd (pg/mL) | Additive error | 3.92 | 12.65 | 3.83 (-3.36~4.80) |
σprop (%) | Proportional error | 7.8 | 26.06 | 7.0 (-8.8~11.9) |
Pharmacodynamics | ||||
BASE (nmol/L) | Baseline of neopterin | 5.85 | 4.17 | 5.88 (5.39~6.34) |
KOUT (h-1) | First-order elimination rate of serum neopterin | 0.0311 | 17.20 | 0.03 (0.02~0.04) |
EMAX | Maximum stimulatory effect | 16.1 | 53.19 | 17.45 (7.06~62.42) |
GA | Hill coefficient (γ) | 1.24 | 11.85 | 1.27 (1.01~2.52) |
CAc | Coefficient | 405 | 115.80 | 616.5 (27~13115) |
CBc | Coefficient | 0.0068 | 27.73 | 0.0064 (0.0014~0.0119) |
ECBc | Baseline of EC50 | 2.17 | 152.07 | 1.66 (0.05~74.67) |
MTT (h) | Mean transit time | 14.6 | 11.37 | 14.5 (9.82~19.2) |
ωBASE (%) | Between subject variability of BASE | 13.85 | 51.84 | 12.63 (3.91~20.79) |
ωCB (%) | Between subject variability of CB | 57.31 | 43.31 | 46.21 (0.32~72.61) |
ωGA (%) | Between subject variability of GA | 13.51 | 55.80 | 13 (0.32~36.49) |
ωECB (%) | Between subject variability of ECB | 21.31 | 172.97 | 21.39 (0.45~55.86) |
ωMTT (%) | Between subject variability of MTT | 13.36 | 94.92 | 10.75 (0.55~24.21) |
σadd (nmol/L) | Additive error | 1.14 | 11.05 | 1.11 (0.95~1.37) |