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Table 3 PK model development process

From: Saturable human neopterin response to interferon-α assessed by a pharmacokinetic-pharmacodynamic model

Step Model testeda Objective function value
1 One-compartment model with first-order absorption 2138.416
  One-compartment model with first-order absorption (with lag-time) 2130.609
2 Two-compartment model with first-order absorption 2037.527
  Two-compartment model with first-order absorption (with lag-time) 1993.071
  Two-compartment model with saturable absorption (Michaelis Menten absorption) 2140.583
3 Two-compartment model with zero-order absorption 1885.795
4 One-compartment model with a mixture of zero and first-order absorption 1879.067
  One-compartment model with Michaelis Menten elimination and a mixture of zero- and first-order absorption 2163.942
  1. aThe elimination process was assumed to follow first-order kinetics.