Table 3 PK model development process
Step | Model testeda | Objective function value |
|---|---|---|
1 | One-compartment model with first-order absorption | 2138.416 |
One-compartment model with first-order absorption (with lag-time) | 2130.609 | |
2 | Two-compartment model with first-order absorption | 2037.527 |
Two-compartment model with first-order absorption (with lag-time) | 1993.071 | |
Two-compartment model with saturable absorption (Michaelis Menten absorption) | 2140.583 | |
3 | Two-compartment model with zero-order absorption | 1885.795 |
4 | One-compartment model with a mixture of zero and first-order absorption | 1879.067 |
One-compartment model with Michaelis Menten elimination and a mixture of zero- and first-order absorption | 2163.942 |