Group | Dose | Formulation | Cmax(pg/mL) | Median Tmax(h) | AUClast(ng·h/mL) |
---|---|---|---|---|---|
Controla (N=8) | 3 MIU | Roferon-A® | 43.27 ± 9.804 (22.66%) | 6 | 0.9664 ± 0.9322 (96.46%) |
1 (N=6) | 9 MIU | SR-IFN-α | 28.33 ± 9.656 (34.08%) | 18 | 2.072 ± 1.134 (54.73%) |
2 (N=6) | 18 MIU | SR-IFN-α | 62.12 ± 15.93 (25.64%) | 24 | 5.373 ± 1.382 (25.72%) |
3 (N=6) | 27 MIU | SR-IFN-α | 65.73 ± 6.702 (10.20%) | 24 | 5.544 ± 0.5509 (9.94%) |
4 (N=6) | 36 MIU | SR-IFN-α | 80.31 ± 9.859 (12.28%) | 24 | 7.151 ± 1.132 (15.83%) |