Figure 6

Visual predictive checks of PK (Top) and PD (Bottom) models. One thousand datasets (24,000 virtual subjects) were simulated using the final PK and PD parameter estimates. The simulated median (solid lines) and 75% prediction intervals (broken lines) were overlaid with observed data. The two rightmost panels presenting medians of all dose groups show dose-linearity in PK, but not in PD.